
Welcome to SABITA’s Scientific Community
Distinguished guests and esteemed colleagues,It is my pleasure to welcome you to the Research Institute for Health Sciences and Technologies (SABITA). As a leading multidisciplinary research hub in Türkiye, SABITA is equipped with cutting-edge core facilities, including Advanced Microscopy, Molecular Cell Biology, Proteomics, Drug Discovery, Bioinformatics, Biomaterials, Electrophysiology and Behavior, and Cognitive Neuroscience. These resources empower scientists to pursue innovative solutions to today’s complex challenges in health sciences and technology. At SABITA, we are dedicated to fostering collaboration, driving innovation, and advancing knowledge that makes a real difference. We are excited to have you join us on this journey of scientific discovery and impact.
Assoc. Prof. Emrah Eroğlu
[email protected]Assoc. Prof. Emrah Eroğlu is the Research Director at SABITA and a Principal Investigator at Istanbul Medipol University. His work focuses on the development of genetically encoded biosensors and chemogenetic tools to explore cellular signaling processes at the single-cell level.
Eroğlu’s research is particularly dedicated to understanding reactive oxygen species (ROS) and reactive nitrogen species (RNS) pathways in vascular cells, shedding light on their roles in neurodegenerative diseases and vascular dysfunctions. His laboratory integrates advanced imaging techniques to study redox signaling and molecular interactions, enabling groundbreaking discoveries in cellular biology.
His academic journey includes postdoctoral fellowships at Harvard Medical School and the Medical University of Graz, where he pioneered novel approaches in redox biology and biosensor development. In 2019, he joined Sabancı University to establish a live-cell imaging laboratory, and in 2022, he relocated his lab to Istanbul Medipol University to leverage SABITA’s world-class facilities.
Eroğlu has received numerous national and international research grants to support his work, which underscores the scientific impact and innovation of his projects.
He has also been recognized with prestigious awards such as the Leopold Flohé Redox Pioneer Young Investigator Award (2022) and the Erwin Schrödinger Fellowship, further highlighting his significant contributions to the scientific community.
Eroğlu is an active member of organizations such as the American Heart Association (AHA) and the Society for Free Radical Research Europe (SFRR-E). He serves on the editorial boards of Redox Biochemistry and Chemistry and Free Radical Biology and Medicine and as a reviewer for leading journals.
Selected Publications;
Bioenergetic shift and proteomic signature induced by lentiviral-transduction of GFP-based biosensors
Barakat S, Çimen Ş, Miri SM, Vatandaslar E, Yelkenci HE, San Martín A, Öztürk G, Eroglu E. Bioenergetic shift and proteomic signature induced by lentiviral-transduction of GFP-based biosensors. Redox Biology. 2024;78:103416.
Genetically encoded biosensors unveil neuronal injury dynamics via multichromatic ATP and calcium imaging
Ghaffari Zaki A, Yiğit EN, Aydın MŞ, Vatandaslar E, Öztürk G, Eroglu E. Genetically encoded biosensors unveil neuronal injury dynamics via multichromatic ATP and calcium imaging. ACS Sensors. 2024 Mar;9(3):1261-1271.
Development of a Chemogenetic Approach to Manipulate Intracellular pH
Ghaffari Zaki A, Miri SM, Çimen Ş, Akgül Çağlar T, Yiğit EN, Aydın MŞ, Öztürk G, Eroglu E. Development of a Chemogenetic Approach to Manipulate Intracellular pH. Journal of the American Chemical Society. 2023 Jun;145(22):11899-11902. doi: 10.1021/jacs.3c00703.
Nitric oxide biosensor uncovers diminished ferrous iron-dependency of cultured cells adapted to physiological oxygen levels
Sevimli G, Smith MJ, Caglar TA, Bilir Ş, Secilmis M, Altun HY, Yigit EN, Yang F, Keeley TP, Malli R, Öztürk G, Mann GE, Eroglu E. Nitric oxide biosensor uncovers diminished ferrous iron-dependency of cultured cells adapted to physiological oxygen levels. Redox Biology. 2022 Jul;53:102319. doi: 10.1016/j.redox.2022.102319.
A Co-Culture-Based Multiparametric Imaging Technique to Dissect Local H2O2 Signals with Targeted HyPer7
Secilmis M, Altun HY, Pilic J, Erdogan YC, Cokluk Z, Ata BN, Sevimli G, Zaki AG, Yigit EN, Öztürk G, Malli R, Eroglu E. A Co-Culture-Based Multiparametric Imaging Technique to Dissect Local H2O2 Signals with Targeted HyPer7. Biosensors. 2021 Sep;11(9):338. doi: 10.3390/bios11090338.
Complexities of the chemogenetic toolkit: Differential mDAAO activation by d-amino substrates and subcellular targeting
Erdogan YC, Altun HY, Secilmis M, Ata BN, Sevimli G, Cokluk Z, Zaki AG, Akgul Caglar T, Sevgen İ, Steinhorn B, Ai H, Öztürk G, Belousov VV, Michel T, Eroglu E. Complexities of the chemogenetic toolkit: Differential mDAAO activation by d-amino substrates and subcellular targeting. Free Radical Biology and Medicine. 2021 Dec;177:132-142. doi: 10.1016/j.freeradbiomed.2021.
Discordance between eNOS phosphorylation and activation revealed by multispectral imaging and chemogenetic methods
Eroglu E, Saravi SSS, Sorrentino A, Steinhorn B, Michel T. Discordance between eNOS phosphorylation and activation revealed by multispectral imaging and chemogenetic methods. PNAS. 2019 Oct;116(40):20210-20217. doi: 10.1073/pnas.
Development of novel FP-based probes for live-cell imaging of nitric oxide dynamics
Eroglu E, Gottschalk B, Charoensin S, Blass S, Bischof H, Rost R, Madreiter-Sokolowski CT, Pelzmann B, Bernhart E, Sattler W, Malinski T, Waldeck-Weiermair M, Graier WF, Malli R. Development of novel FP-based probes for live-cell imaging of nitric oxide dynamics. Nature Communications. 2016 Feb;7:10623. doi: 10.1038/ncomms10623.
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Our faculty member Dr. Emrah Eroğlu has been awarded with research funding from European Molecular Biology Organization (EMBO). Dr. Emrah Eroğlu, conducting his research at Istanbul […]
Eylül 26, 2022
Emrah Eroğlu Was Awarded The Leopold Flohé Redox Pioneer Young Researcher Award Emrah Eroğlu, member of Istanbul Medipol University, has been found deserving of the Leopold […]