Cagavi Lab/Cardiovascular and Stem Cell Research Group
Our lab is focused on in vitro and in vivo cardiovascular disease models, systemic interactions of cardiac and nervous systems, and regenerative cell therapies. We use cutting-edge molecular techniques including but not restricted to in vivo transgenic models, experimental cardiac cell therapy, CRISPR/Cas9 genome engineering, optogenetics, and organ-on-chips.
Research Overview
Research Approach
Currently, Dr. Cagavi’s research group is pursuing research on:
• Cardiovascular disease models, in particular congenital forms of arrhythmia,
• In vitro by patient-derived human induced pluripotent stem cells
• Molecular investigation of cardiac disease
• Cardiac and nervous systems interactions at the system level
• Mapping the sensorial innervations of the heart
• Cardiac immunology at diseased state
We are using a variety of cutting-edge molecular tools and approaches including patient-derived induced pluripotent stem cells (iPSC), in vitro cardiac and neuronal differentiation of iPSCs, CRISPR/Cas9 genome engineering, microfluidic systems, electrode array systems for electrophysiological analysis, immunohistochemistry and tissue clearance techniques, tissue engineering, optogenetics, chemogenetics, and transgenic mouse models.
