Proteomics and Metabolomics
Our laboratory is equipped with cutting-edge mass spectrometry technology, delivering advanced solutions in the fields of proteomics and metabolomics.
Our Services
Expert preparation of diverse samples for precise analysis
Comprehensive untargeted proteomics and metabolomics analysis
Advanced data analysis and statistical evaluation
Working Area & Solutions
Our facility is equipped with state-of-the-art instruments. These technologies provide unmatched precision for proteomics, metabolomics, and trace element analysis, ensuring reliable results.
Our team of experienced scientists supports you throughout your research journey. From experimental design to data analysis, we provide the expertise needed to optimize your studies and obtain the most accurate results.
We value collaboration and work closely with researchers from İstanbul Medipol University and beyond. Our team provides the resources, expertise, and innovative tools required to drive your research forward.
We are committed to delivering the highest quality analysis with exceptional sensitivity and precision, ensuring reliable data that supports impactful scientific discoveries.
Each research project is unique. We provide personalized support and workflows designed to meet your specific objectives, whether you are a seasoned researcher or new to omics studies.
Comprehensive Services: We offer a wide range of services, including untargeted proteomics and metabolomics analysis, targeted quantitative analysis.
Each research project is unique: Tailored consultation for experimental design to optimize your research.
- Expert preparation of diverse samples for precise analysis (cells, body fluids, tissues, etc.)
- Comprehensive untargeted proteomics and metabolomics analysis for in-depth insights
- Advanced data analysis and statistical evaluation to ensure robust findings
- Detailed consultation and clear interpretation of results to help you make informed decisions
- High-precision ICP-MS analysis for trace elements, heavy metals, and minerals in biological samples
- Advanced HPLC systems for fractionation and chemical analysis of complex mixtures
- MALDI analysis for high-resolution biomolecular identification
SABITA-MODAS offers cutting-edge technology, expert guidance, and a comprehensive range of services to support your omics research.
INSTRUMENT
AND
CAPABILITY
The SYNAPT G2-Si (Waters) is a hybrid quadrupole-time-of-flight (Q-TOF) mass spectrometer, featuring a traveling wave ion-mobility separation cell. This innovative design enables the separation of gaseous ions not only by mass but also by their structural characteristics. The SYNAPT G2 is integrated with both Acquity UPLC M-Class and I-Class systems (Waters). Available ion sources include Electrospray Ionization (ESI), nanoESI, and Matrix-assisted laser desorption/ionization (MALDI). The QTOF features a resolving quadrupole, an ion mobility drift cell, two collision cells, and a TOF with a resolving power greater than 40,000 FWHM. The LockSpray reference mass enhances mass accuracy, while the StepWave ion optics improve sensitivity. This instrument supports MS/MS, MSE, and corresponding HDMS (with ion mobility) experiments. Both the LC and MS systems are operated using MassLynxTM software, and more advanced analyses are possible with Progenesis QI and Progenesis QI for proteomics.
Waters Xevo TQ-S + I-Class UPLC is a highly sensitive and powerful tandem quadrupole mass spectrometer coupled with the I-Class UPLC system. The combination of these two instruments provides exceptional analytical performance for a wide range of applications, including targeted quantitative analysis and small molecule characterization.
HPLC is a high-performance version of liquid chromatography and is commonly used for the separation, identification, and analysis of chemical compounds. HPLC is a fundamental technique in analytical laboratories for a range of chemical analyses, particularly in the determination of biomolecules, pharmaceuticals, environmental pollutants, and food compounds.
ICP-MS is an advanced technique that enables the analysis of elements and trace elements with high precision. This technology plays an important role in the detection of trace elements, heavy metals, and minerals in environmental and biological samples.
Dr. Hayriye Ecem Yelkenci
Comprehensive workflow experience in bottom-up shotgun proteomics, involving sample preparation, UPLC-QTOF-based mass spectrometry, bioinformatics and biostatistical analysis.
Bahadır Açıktepe (MSc)
Expertise has been developed in bioinformatics, biostatistics and statistical analysis using programming tools. Experience has been gained in proteomic sample preparation, ICP-MS operations, and method validation for biological data interpretation.
Dr. Sarah Barakat
Multiomics data analysis, with particular expertise in proteomics and integrated approaches to investigate cellular mechanisms and molecular interactions.
Elif Özbay (MSc)
Experienced proteomics researcher specialized in biomarker discovery using shotgun, bottom-up and DIA strategies. Research interests include molecular signaling and neurodegenerative disorders.
Dr. İhsan Yozgat is an experienced researcher in medical biotechnology, analytical chemistry, and mass spectrometry, with over 15 years in both academia and industry. He holds a Ph.D. in Medical Biotechnology and an M.Sc. in Analytical Chemistry. His Ph.D. focused on non-targeted metabolomic profiling of urine to monitor kidney transplant patients using LC-MS/MS and bioinformatics.
He specializes in high-resolution mass spectrometry platforms like UPLC-QTOF and MALDI-TOF for analyzing various biological samples. He has participated in TÜBİTAK-funded projects and co-authored peer-reviewed publications. His research interests include biomarker discovery, multi-omics integration, AI in biomedicine, and applications in nephrology and oncology. Dr. Yozgat has also gained experience at renowned institutions such as İstanbul Medipol University REMER and Memorial Sloan Kettering Cancer Center.