Hayriye Ecem Yelkenci
[email protected]She received her B.Sc., M.Sc., and Ph.D. degrees from Istanbul Technical University (ITU). Since 2019, she has been working as a researcher at Istanbul Medipol University-SABITA, and in 2025 she was promoted to senior researcher. Her work primarily focuses on shotgun bottom-up proteomics, encompassing the complete workflow of proteomic studies, including sample preprocessing, Q-TOF mass spectrometry operation and data acquisition, computational data processing using bioinformatics software, and comprehensive biostatistical analyses. She has applied these methodologies across a variety of biological matrices and pathological conditions, with a particular emphasis on neurodegenerative diseases. Through this work, she has gained substantial experience in both the generation and interpretation of large-scale proteomic datasets, contributing to the identification of disease-related molecular mechanisms and potential therapeutic targets.
Selected Publications;
Exploring the Proteomic Signature of Diabetic Nephropathy: Implications for Early Diagnosis and Treatment
Sari-Ak, D.; Con, F.; Helvaci, N.; Yelkenci, H. E.; Kural, A.; Can, O.; Beker, M. C. Exploring the Proteomic Signature of Diabetic Nephropathy: Implications for Early Diagnosis and Treatment. Life 2025, 15 (8), 1312.
Circadian Rhythm Disruption Exacerbates Neurodegeneration and Alters Proteomic Profiles in a 6-OHDA Induced Parkinson’s Disease Model
Koc, H. I.; Dogan, E.; Yelkenci, H. E.; Bayraktaroglu, C.; Ozpinar, A.; Balaban, B.; … Circadian Rhythm Disruption Exacerbates Neurodegeneration and Alters Proteomic Profiles in a 6-OHDA Induced Parkinson’s Disease Model. Exp. Neurol. 2025, 115356.
Proteomic Data and Drug Implications for Cerebral Microvascular Endothelial Cells under Varying Oxygen Levels
Barakat, S.; Yang, F.; Yelkenci, H. E.; Kök, K.; Mann, G. E.; Eroğlu, E. Proteomic Data and Drug Implications for Cerebral Microvascular Endothelial Cells under Varying Oxygen Levels. Sci. Data 2025, 12 (1), 989.
Vinpocetine Ameliorates Neuronal Injury after Cold-Induced Traumatic Brain Injury in Mice
Yelkenci, H. E.; Degirmenci, Z.; Koc, H. I.; Bayirli, S.; Baltaci, S. B.; Altunay, S.; … Vinpocetine Ameliorates Neuronal Injury after Cold-Induced Traumatic Brain Injury in Mice. Mol. Neurobiol. 2025, 62 (3), 3956–3972.
Effects of Circadian Rhythm Disruption on Cellular Survival and Brain Protein Profile in an Experimental Parkinson’s Model
Dogan, E.; Koc, H. I.; Yelkenci, H. E.; Bayraktaroglu, C.; Ozpinar, A.; Balaban, B.; … Effects of Circadian Rhythm Disruption on Cellular Survival and Brain Protein Profile in an Experimental Parkinson’s Model. Acta Physiol. 2025, 241, 53–53.
Intergenerational Conditioning via Intermittent Parental Hypoxia Confers Stroke Resilience in Offspring
Caglayan, A. B.; Beker, M. C.; Felix-Ilemhenbhio, F.; Altunay, S.; Yelkenci, H. E.; … Intergenerational Conditioning via Intermittent Parental Hypoxia Confers Stroke Resilience in Offspring. bioRxiv 2025, 2025.07.02.662697.
Bioenergetic Shift and Proteomic Signature Induced by Lentiviral-Transduction of GFP-Based Biosensors
Barakat, S.; Çimen, Ş.; Miri, S. M.; Vatandaşlar, E.; Yelkenci, H. E.; San Martín, A.; … Bioenergetic Shift and Proteomic Signature Induced by Lentiviral-Transduction of GFP-Based Biosensors. Redox Biol. 2025, 78, 103416.
Phosphodiesterase 10A Deactivation Induces Long-Term Neurological Recovery, Peri-Infarct Remodeling and Pyramidal Tract Plasticity after Transient Focal Cerebral Ischemia in Mice
Beker, M. C.; Pence, M. E.; Yagmur, S.; Caglayan, B.; Caglayan, A.; Kilic, U.; … Phosphodiesterase 10A Deactivation Induces Long-Term Neurological Recovery, Peri-Infarct Remodeling and Pyramidal Tract Plasticity after Transient Focal Cerebral Ischemia in Mice. Exp. Neurol. 2025, 358, 114221.
Identification of PDE10A Related Proteins via Proteomic Analysis
Beker M.C., Yelkenci H.E., Caglayan B., Kiliç E., "Identification of PDE10A Related Proteins via Proteomic Analysis", Annals of Medical Research, 2022;29(8):894-899.
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Şubat 16, 2026
We at MODAS (Multi-Omics & Design and Analysis Studio) are excited to announce this month’s MODAS WS, titled Proteomics in Practice: Concepts, Workflow and Data Interpretation. […]