Prof. Dr. Mustafa Güzel
[email protected]Dr. Guzel graduated from Hacettepe University School of Engineering with a B. Sc degree in Chemistry in 1987 and completed his M. Sc. and Ph. D. Degrees on Organic/Medicinal Chemistry at Clemson University, Clemson, SC in 1996 and 2001 respectively. He worked as organic lab coordinator at Northeastern University and later joined to ArQule Inc.as Sr. Synthetic Organic Chemist upon his graduation. He then joined to TransTech Pharma Inc, in High Point, NC and assumed various positions in Medicinal Chemistry Department between 2001 and 2014. In 2014 he started working as an Assistant Professor at International School of Medicine in Department of Medical Pharmacology at Istanbul Medipol University. In 2017 he was promoted to Associate Professor in medical pharmacology acting as a chair. In 2019 he was appointed as the department chair of Molecular Medicine and Biotechnology. In January 2020, he then became the director of Drug Discovery and Development Research Center in newly established Health Sciences and Technologies Research Institute, currently leading two critical drug development projects for Covid-19 with a local pharma company as well as several domestic and European granted drug discovery projects in Molecular Discovery and Development laboratories of the university.
Selected Publications;
Instant Determination of the Artemisinin from Various Artemisia annua Extracts and Their in Silico Modelling & in Vitro Anti-Viral Activity Studies Against SARS-CoV-2
“Instant Determination of the Artemisinin from Various Artemisia annua Extracts and Their in Silico Modelling & in Vitro Anti-Viral Activity Studies Against SARS-CoV-2”; Kubra Dogan, Ebru Erol, Muge Didem Orhan, Zehra Değirmenci, Tugce Kan, Aysen Gungor, Belkis Yasa, Timucin Avsar, Yuksel Cetin, Serdar Durdagi, and Mustafa Guzel; Journal of Ethnopharmacology, 2021, manuscript submitted.
Cost Effective Industrial Scale Bulk Synthesis of Favipiravir to Domestically Combat with Covid-19
“Cost Effective Industrial Scale Bulk Synthesis of Favipiravir to Domestically Combat with Covid-19”; Hacer Karatas, Essam A. H. Alshahaby, Yasar Enes Butun, Zeynep Atabay Taskent, Sahin Gursel, Adil, Kaya and Mustafa Guzel; TPO-Patent, 2021, patent submitted.
Novel Strategies for the Synthesis of A2A Adenosine Receptor Antagonist Analogs
“Novel Strategies for the Synthesis of A2A Adenosine Receptor Antagonist Analogs”; Şükran Özdatlı, Hanife Pekel, Bilgesu Onur Sucu, and Mustafa Guzel; European Journal of Medicinal Chemistry, 2021, manuscript in preparation.
The Neutralization Effect of Montelukast on SARS-CoV-2 is Shown by Multiscale in Silico Simulations and Combined in Vitro Studies
“The Neutralization Effect of Montelukast on SARS-CoV-2 is Shown by Multiscale in Silico Simulations and
Combined in Vitro Studies”; Serdar Durdagi, Timucin Avsar, Muge Didem Orhan, Muge Serhatli, Bertan Koray Balcioglu, Hasan Umit Ozturk, Alisan Kayabolen, Yuksel Cetin, Seyma Aydinlik, Tugba Bagci-Onder, Saban Tekin, Hasan Demirci, Mustafa Guzel, Atilla Akdemir, Seyma Calis, Lalehan Oktay, Ilayda Tolu, Yasar Enes Butun, Ece Erdemoglu, Alpsu Olkan, Nurettin Tokay, Seyma Işik, Aysenur Ozcan, Elif Acar, Sehriban Buyukkilic, Yesim Yumak; Nature Communications, volume: 12, number: 1410, page: 1-37, 2021. DOI: 10.1101/2020.12.26.424423.
Design and Synthesis of Novel Caffeic Acid Phenethyl Ester (CAPE) Derivatives and Their Biological Activity Studies in Glioblastoma Multiforme (GBM) Cancer Cell Lines
“Design and Synthesis of Novel Caffeic Acid Phenethyl Ester (CAPE) Derivatives and Their Biological Activity Studies in Glioblastoma Multiforme (GBM) Cancer Cell Lines”; Bilgesu Onur Sucu, Elif Beyza Koc, Ozgecan Savlug Ipek, Afranur Mirat, Furkan Almas,, Melike Aybal Guzel, Nihal Karakas, Berna Dogan, Serdar Durdagi, and Mustafa Guzel; Tetrahedron, 2021, manuscript submitted.
Antifungal and Antibacterial Activity of Some Marine Invertebrates from Turkish Coastlines
“Antifungal and Antibacterial Activity of Some Marine Invertebrates from Turkish Coastlines”; Ayse Esra Karadag, Hajar Heydari, Ismail Korpe, Belma Konuklugil, Betul Giray, and Mustafa Guzel; Frontiers in Microbiology, 2020, manuscript submitted.
Design and synthesis of novel cylopentapyrazoles bearing 1,2,3-thiadiazole moiety as potent antifungal agents
“Design and synthesis of novel cylopentapyrazoles bearing 1,2,3-thiadiazole moiety as potent antifungal agents”; Betül Giray, Ayse Esra Karadag, Ozgecan Savlug Ipek, Hanife Pekel, Mustafa Guzel, and Hatice Baspinar Kucuk; Biorganic Chemistry, vol:95, p:103509, 2020, DOI: 10.1016/j.bioorg.2019.103509.
Novel Heteroaryl-Pyrazole Derivative Molecules and Their Use as Antigungal Agents
Novel Heteroaryl-Pyrazole Derivative Molecules and Their Use as Antigungal Agents”; Hatice Baspinar Kucuk, Mustafa Guzel, Ayse Esra Karadag, Betül Giray, and Ozgecan Savlug Ipek; TR Patent, Istanbul Medipol University, Istanbul, Patent No: 2019/06570, 02/05/2019.
Novel Synthetic Approaches for Bisnaphthalimidopropyl (BNIP) Derivatives as Anti-Parasitic Agents for the Treatment of Leishmaniasis
“Novel Synthetic Approaches for Bisnaphthalimidopropyl (BNIP) Derivatives as Anti-Parasitic Agents for the Treatment of Leishmaniasis”; Elif Keskin, Mehmet Hikmet Ucisik, Bilgesu Onur Sucu, and Mustafa Guzel; Molecules, Volume: 24, No:24, 2019, doi:10.3390/molecules24244607.
Identification and in-vitro Bioactivity Screening of Some Marine-Derived Fungi from Turkish Coastlines
“Identification and in-vitro Bioactivity Screening of Some Marine-Derived Fungi from Turkish Coastlines”; Hajar Heydari, Aslı Koc, Belma Konuklugil, Betul Giray, Ayse Esra Karadag, and Mustafa Guzel; Frontiers in Microbiology, 2019, manuscript submitted.
Synthesis of Novel Methyl Jasmonate Derivatives and Evaluation of Their Biological Activity in Various Cancer Cell Lines
“Synthesis of Novel Methyl Jasmonate Derivatives and Evaluation of Their Biological Activity in Various Cancer Cell Lines”; Bilgesu Onur Sucu, Ozgecan Savlug Ipek, Sukran Ozdatli Kurtulus, Busra Emine Yazici, Nihal
Karakas, and Mustafa Guzel; Bioorganic Chemistry, Volume: 91, 2019, p: 103146.
(https://doi.org/10.1016/j.bioorg.2019.103146).
Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model
“Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model”; Raziye
Piranlioglu, EunMi Lee, Maria Ouzounova, Roni J. Bollag, Alicia H. Vinyard, Ali S. Arbab, Daniela Marasco, Mustafa Guzel, John K. Cowell, Muthushamy Thangaraju, Ahmed Chadli, Khaled A. Hassan, Max S. Wicha, Esteban Celis and Hasan Korkaya; Nature Communications, volume: 10, number: 1410, pages: 1-13, 2019. DOI: 10.1038/s41467-019-09015-1.
The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20
“The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20”; Eunmi Lee, Maria Ouzounova, Raziye Piranlioglu, Minh Thu Ma, Mustafa Guzel, Daniela Marasco, Ahmed Chadli, Jason E. Gestwicki, John K. Cowell, Max S. Wicha, Khaled A. Hassan, and Hasan Korkaya; Oncogene, volume: 37, number: 36, pages: 1-14, 2019. DOI: 10.1038/s41388-018-0472-0.
Heterobivalent Ligands Suitable for Use in The Treatment of Parkinson's Disease
“Heterobivalent Ligands Suitable for Use in The Treatment of Parkinson's Disease”; Ozge Sensoy, Mustafa Guzel, Bilal Ersen Kerman, Neslihan Ustundag Okur, Samman Mansoor, Essam Alshahaby, Elif Keskin, Serdar Durdagi, and Gulru Kayik; WO Patent, Istanbul Medipol University and Bahcesehir University, Istanbul, Patent No: WO2019004970, 03/01/2019.
Novel Bisnapthalimidopropyl (BNIP) Derivatives as Active Pharmaceutical Ingredients
“Novel Bisnapthalimidopropyl (BNIP) Derivatives as Active Pharmaceutical Ingredients”; Mustafa Guzel, Mehmet Hikmet Ucisik, Fikrettin Sahin, Elif Keskin, and Zeynep Islek; TR Patent, Istanbul Medipol University, and Yeditepe University, Istanbul, Patent No: 2018/20740, 27/12/2018.
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