Prof. Dr. Esra Çağavi
[email protected]Dr. Esra Cagavi received her bachelor’s degree from the Department of Molecular Biology and Genetics at Bosphorus (Bogazici) University in 2002. The following year she joined Dr. Gerry Weinmaster’s lab at David Geffen School of Medicine at UCLA. During her Ph.D. studies, she elucidated the ligand-induced or ligand-independent mechanism of Notch signal activation by metalloproteases in the mammalian system. After completing her graduate studies at UCLA, as a postdoctoral fellow, she joined Dr. Yibing Qyang’s lab at the Stem Cell Center and Cardiovascular Research Center at Yale University. During her postdoctoral training, she specialized in cardiac development, cardiovascular diseases, stem cell biology, in vitro cardiac differentiation, and using stem cells as disease models and regenerative translational therapeutic tools. Her research interests over the years have diversified and expanded, remaining focused on the cardiac system. Her lab uses cutting-edge molecular techniques including but not restricted to in vivo transgenic models, experimental cardiac cell therapy, CRISPR/Cas9 genome engineering, optogenetics, and organ-on-chips.
Currently, Dr. Cagavi’s research group is pursuing research on:
- Cardiovascular disease models, in particular congenital forms of arrhythmia,
- In vitro by patient-derived human induced pluripotent stem cells
- Molecular investigation of cardiac disease
- Cardiac and nervous systems interactions at the system level
- Mapping the sensorial innervations of the heart
- Cardiac immunology at diseased state
Selected Publications;
High-Resolution Mapping of Sensory Fibers at the Healthy and Post-Myocardial Infarct Whole Transgenic Hearts
Sahoglu SG, Kazci YE, Karadogan B, Aydin MS, Nebol A, Turhan MU, Ozturk G, Cagavi E. High-resolution mapping of sensory fibers at the healthy and post-myocardial infarct whole transgenic hearts. J Neurosci Res. 2022 Dec 14. doi: 10.1002/jnr.25150. Epub ahead of print. PMID: 36517461.
Human macrophages directly modulate iPSC-derived cardiomyocytes at healthy state and congenital arrhythmia model in vitro
Koc, A., Akdeniz, C. & Cagavi, E. Human macrophages directly modulate iPSC-derived cardiomyocytes at healthy state and congenital arrhythmia model in vitro. Pflugers Arch - Eur J Physiol (2022).
Functional evaluation of the tachycardia patient-derived iPSC cardiomyocytes carrying a novel pathogenic SCN5A variant
Goktas Sahoglu S, Kazci YE, Tuncay E, Torun T, Akdeniz C, Tuzcu V, Cagavi E. Functional evaluation of the tachycardia patient-derived iPSC cardiomyocytes carrying a novel pathogenic SCN5A variant. J Cell Physiol. 2022 Aug 12. doi: 10.1002/jcp.30843.
Anatomical characterization of vagal nodose afferent innervation and ending morphologies at the murine heart using a transgenic approach
Yusuf Enes Kazci, Sevilay Sahoglu Goktas, Mehmet Serif Aydin, Behnaz Karadogan, Aylin Nebol, Mehmet Ugurcan Turhan, Gurkan Ozturk, Esra Cagavi."Anatomical characterization of vagal nodose afferent innervation and ending morphologies at the murine heart using a transgenic approach" Autonomic Neuroscience,242,(2022).
Defining Optimal Enzyme and Matrix Combination for Replating of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes at Different Levels of Maturity
Koç, A., Sahoglu Göktas, S., Akgul Caglar, T. & Cagavi, E. (2021). Defining Optimal Enzyme and Matrix Combination for Replating of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes at Different Levels of Maturity. Experimental Cell Research.
Experimental data of labeling the heart and cardiac cultures with a retrograde tracer in vitro and in vivo
Akgul Caglar, T., Gunal, M. Y., Turhan, M. U., Ozturk, G., & Cagavi, E. (2021). Experimental data of labeling the heart and cardiac cultures with a retrograde tracer in vitro and in vivo. Data in Brief, 35, 106834.
Zero‐valent iron nanoparticles containing nanofiber scaffolds for nerve tissue engineering
Aydemir Sezer, U, Ozturk Yavuz, K, Ors, G, et al. Zero‐valent iron nanoparticles containing nanofiber scaffolds for nerve tissue engineering. J Tissue Eng Regen Med. 2020; 1– 12.
Evaluation of the Bilateral Cardiac Afferent Distribution at the Spinal and Vagal Ganglia by Retrograde Labeling
Akgul Caglar, T., Durdu, Z. B., Turhan, M. U., Gunal, M. Y., Aydın, M. S., Ozturk, G., & Cagavi, E.. “Evaluation of the Bilateral Cardiac Afferent Distribution at the Spinal and Vagal Ganglia by Retrograde Labeling ” Brain Research, 1751,(2021).
Cardiac Immunology: A New Era for Immune Cells in the Heart
Koc A, Cagavi E. “Cardiac Immunology: A New Era for Immune Cells in the Heart” Advances in Experimental Medicine and Biology. 1-21. Springer, New York, NY, (2020).
8. Patient-specific induced pluripotent stem cells for cardiac disease modeling
Cagavi, E., Caglar, T., Haider, K., & Soztekin, G. “8. Patient-specific induced pluripotent stem cells for cardiac disease modeling” Stem Cells – From Hype to Real Hope. 146-172. Berlin, Boston: De Gruyter (2018).
The Heart of The Matter: Cardiac Stem Cells
Cagavi E., Koc A., Sahoglu Goktas S. “ The Heart of The Matter: Cardiac Stem cells” Turkish J Biol 40: 968-980 (2016).
Stem Cells: Biology Genetics, and Epigenetics
Cagavi E., Ozoren N. Editorial, Special Issue, “Stem Cells: Biology Genetics, and Epigenetics” Turkish J Biol 40 (5) Pages I-II (2016).
Functional Cardiomyocytes Derived From Isl1 Cardiac Progenitors Via Bmp4 Stimulation
Cagavi E. , Bartulos O., Suh C. Y., Sun B., Yue Z., Jiang Z., Yue L., Qyang Y. “Functional Cardiomyocytes Derived From Isl1 Cardiac Progenitors Via Bmp4 Stimulation” Plos One (2014).
Bone Morphogenetic Protein 2 Signaling Negatively Modulates Lymphatic Development in Vertebrate Embryos
Dunworth W. P., Cardona-Costa J., Cagavi E., Kim J. D., Meadows S., Fisher J. C., Wang Y., Cleaver O., Qyang Y., Ober E. A., and Jin S. W. “Bone Morphogenetic Protein 2 Signaling Negatively Modulates Lymphatic Development in Vertebrate Embryos” Circ Res 114 (1) :56-66 (2014).
Modeling Supravalvular Aortic Stenosis Syndrome Using Human Induced Pluripotent Stem Cells
Ge X., Ren Y., Bartulos O., Lee M. Y., Yue Z, Kim K. Y., Li W., Amos P. J., Cagavi Bozkulak E., Iyer A., Zheng W., Zhao H., Martin K. A., Kotton D. N., Tellides G., Park I. H., Yue L., Qyang Y. “Modeling Supravalvular Aortic Stenosis Syndrome Using Human Induced Pluripotent Stem Cells” Circulation 126(14):1695-704 (2012).
Regenerating Functional Heart Tissue for Myocardial Repair
Alcon A., Cagavi Bozkulak E., Qyang Y. “Regenerating Functional Heart Tissue for Myocardial Repair” Cell Mol Life Sci 69(16):2635-56 (2012).
Methods of Cell Purification: A Critical Juncture for Laboratory Research and Translational Science
Amos P. J., Cagavi Bozkulak E., Qyang Y. “Methods of Cell Purification: A Critical Juncture for Laboratory Research and Translational Science” Cells Tissues Organs 195(1-2):26-40 (2012).
Derivation of Functional Ventricular Cardiomyocytes Using Endogenous Promoter Sequence from Murine Embryonic Stem Cells
Lee M. Y., Sun B., Schliffke S., Yue Z., Ye M., Paavola J, Cagavi Bozkulak E., Amos P.J., Ren Y., Ju R., Jung Y. W., Ge X., Yue L., Ehrlich B. E., Qyang Y. “Derivation of Functional Ventricular Cardiomyocytes Using Endogenous Promoter Sequence from Murine Embryonic Stem Cells” Stem Cell Res 8, 49–57 (2011).
High Density Cultures of Embryoid Bodies Enhanced Cardiac Differentiation of Murine Embryonic Stem Cells
Lee M. Y., Cagavi Bozkulak E., Schliffke S., Amos P. J., Ren Y., Ge X., Ehrlich B. E., Qyang Y. “High Density Cultures of Embryoid Bodies Enhanced Cardiac Differentiation of Murine Embryonic Stem Cells” Biochem Biophys Res Commun 416, 51-57 (2011).
Selective Use of ADAM10 and ADAM17 in Activation of Notch1 Signaling
Bozkulak E. C., Weinmaster G. “Selective Use of ADAM10 and ADAM17 in Activation of Notch1 Signaling” Mol Cell Bio 29(21), 5679–5695 (2009).
Roles for SR Proteins and hnRNP A1 in the Regulation of c-src Exon N1
Rooke N., Vadim M., Cagavi E., Black D. L. “Roles for SR Proteins and hnRNP A1 in the Regulation of c-src Exon N1” Mol Cell Bio 23(6), 1874-1884 (2003).
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Nisan 24, 2023
We present you the new episode of our podcast series on heart health week, one of Prof. Esra Çağavi‘s research topics. In our latest scientific conversation, […]