Assoc. Prof. Mazdak Ganjali Khani Hakemi
[email protected]Mazdak obtained his BSc degree in Medical Laboratory Sciences from Iran University of Medical Sciences in 1999. Subsequently, he pursued his MSc in Medical Immunology at Tehran University of Medical Sciences, completing the program in 2002. In 2006, Mazdak commenced his PhD program in Medical Immunology at Isfahan University of Medical Sciences, with a specific focus on cellular and molecular immunology. During the course of his doctoral studies, he spent a sabbatical period at Ludwig-Maximilian University in Munich, Germany. He successfully defended his PhD thesis in 2011.
He commenced his academic journey as an assistant professor at Isfahan University of Medical Sciences in Iran in 2011. Over the years, his dedication and contributions led to his appointment as an associate professor, a position he held from 2017 to 2022 at the same institution. Seeking new horizons, he transitioned to Yeditepe University in Istanbul, serving as a guest professor for 10 months. Subsequently, he joined Istanbul Medipol University as a member of SABITA, marking the beginning of his current responsibilities.
Throughout his professional tenure, he has been actively involved in teaching diverse courses on Immunology and related disciplines for both undergraduate and graduate students. An integral part of his academic portfolio includes supervising over 60 Ph.D. and M.Sc. theses, alongside the publication of more than 140 peer-reviewed scientific articles in esteemed international journals. In addition, he has successfully obtained three national patents and authored 20 books. His research focus primarily centers around molecular immunology, with a specialization in cancer and autoimmune disorders, reflecting his commitment to advancing knowledge and contributing to the understanding of these critical fields.
Selected Publications;
TIM-3/Galectin-9 interaction and glutamine metabolism in AML cell lines, HL-60 and THP-1
Shapourian, H., Ghanadian, M., Eskandari, N. et al. TIM-3/Galectin-9 interaction and glutamine metabolism in AML cell lines, HL-60 and THP-1. BMC Cancer 24, 125 (2024). https://doi.org/10.1186/s12885-024-11898-3
TIM-3/Gal-9 interaction affects glucose and lipid metabolism in acute myeloid leukemia cell lines
Rezaei M, Ghanadian M, Ghezelbash B, Shokouhi A, Bazhin AV, Zamyatnin AA Jr, Ganjalikhani-Hakemi M. TIM-3/Gal-9 interaction affects glucose and lipid metabolism in acute myeloid leukemia cell lines. Front Immunol. 2023 Nov 10;14:1267578. doi: 10.3389/fimmu.2023.1267578. PMID: 38022614; PMCID: PMC10667689.
PD-L1 stimulation can promote proliferation and survival of leukemic cells by influencing glucose and fatty acid metabolism in acute myeloid leukemia
Soltani, M., Ghanadian, M., Ghezelbash, B. et al. PD-L1 stimulation can promote proliferation and survival of leukemic cells by influencing glucose and fatty acid metabolism in acute myeloid leukemia. BMC Cancer 23, 447 (2023). https://doi.org/10.1186/s12885-023-10947-7
The role of miRNAs from mesenchymal stem/stromal cells-derived extracellular vesicles in neurological disorders
Jafarinia, M., Farrokhi, M.R., Ganjalikhani Hakemi, M. et al. The role of miRNAs from mesenchymal stem/stromal cells-derived extracellular vesicles in neurological disorders. Human Cell 36, 62–75 (2023). https://doi.org/10.1007/s13577-022-00813-2
Transplantation of human adipose-derived stem cells overexpressing LIF/IFN-β promotes recovery in experimental autoimmune encephalomyelitis (EAE)
Yousefi, M., Nabipour, A., Ganjalikhani Hakemi, M. et al. Transplantation of human adipose-derived stem cells overexpressing LIF/IFN-β promotes recovery in experimental autoimmune encephalomyelitis (EAE). Sci Rep 12, 17835 (2022). https://doi.org/10.1038/s41598-022-21850-9
Cancer Vaccine in Cold Tumors: Clinical Landscape, Challenges, and Opportunities
Rezaei M, Danilova ND, Soltani M, Savvateeva LV, Tarasov VV, Ganjalikhani-Hakemi M, Bazhin AV, Zamyatnin AA. Cancer Vaccine in Cold Tumors: Clinical Landscape, Challenges, and Opportunities. Curr Cancer Drug Targets. 2022;22(6):437-453. doi: 10.2174/1568009622666220214103533. PMID: 35156572.
mRNA-Based Cancer Vaccines: A Therapeutic Strategy for the Treatment of Melanoma Patients
Bidram, Maryam, Yue Zhao, Natalia G. Shebardina, Alexey V. Baldin, Alexandr V. Bazhin, Mohamad Reza Ganjalikhany, Andrey A. Zamyatnin, Jr., and Mazdak Ganjalikhani-hakemi. 2021. "mRNA-Based Cancer Vaccines: A Therapeutic Strategy for the Treatment of Melanoma Patients" Vaccines 9, no. 10: 1060. https://doi.org/10.3390/vaccines9101060
TIM-3 in Leukemia; Immune Response and Beyond
Rezaei M, Tan J, Zeng C, Li Y, Ganjalikhani-Hakemi M. TIM-3 in Leukemia; Immune Response and Beyond. Front Oncol. 2021 Sep 30;11:753677. doi: 10.3389/fonc.2021.753677. PMID: 34660319; PMCID: PMC8514831.
Cutting edge: Metabolic immune reprogramming, reactive oxygen species, and cancer
Aria H, Ghaedrahmati F, Ganjalikhani-Hakemi M. Cutting edge: Metabolic immune reprogramming, reactive oxygen species, and cancer. J Cell Physiol. 2021 Sep;236(9):6168-6189. doi: 10.1002/jcp.30303. Epub 2021 Feb 9. PMID: 33561318.
A Novel CAR Expressing NK Cell Targeting CD25 With the Prospect of Overcoming Immune Escape Mechanism in Cancers
Dehbashi M, Hojati Z, Motovali-Bashi M, Ganjalikhany MR, Cho WC, Shimosaka A, Navabi P, Ganjalikhani-Hakemi M. A Novel CAR Expressing NK Cell Targeting CD25 With the Prospect of Overcoming Immune Escape Mechanism in Cancers. Front Oncol. 2021 May 14;11:649710. doi: 10.3389/fonc.2021.649710. PMID: 34055618; PMCID: PMC8160382.
Therapeutic effects of extracellular vesicles from human adipose-derived mesenchymal stem cells on chronic experimental autoimmune encephalomyelitis
Jafarinia M, Alsahebfosoul F, Salehi H, Eskandari N, Azimzadeh M, Mahmoodi M, Asgary S, Ganjalikhani Hakemi M. Therapeutic effects of extracellular vesicles from human adipose-derived mesenchymal stem cells on chronic experimental autoimmune encephalomyelitis. J Cell Physiol. 2020 Nov;235(11):8779-8790. doi: 10.1002/jcp.29721. Epub 2020 Apr 24. PMID: 32329062.
Impact of IFN-β and LIF overexpression on human adipose-derived stem cells properties
Ashja-Arvan M, Dehbashi M, Eslami A, Salehi H, Yoosefi M, Ganjalikhani-Hakemi M. Impact of IFN-β and LIF overexpression on human adipose-derived stem cells properties. J Cell Physiol. 2020 Nov;235(11):8736-8746. doi: 10.1002/jcp.29717. Epub 2020 Apr 23. PMID: 32324266.
The immunoregulatory and neuroprotective effects of human adipose derived stem cells overexpressing IL-11 and IL-13 in the experimental autoimmune encephalomyelitis mice
Azimzadeh M, Mahmoodi M, Kazemi M, Hakemi MG, Jafarinia M, Eslami A, Salehi H, Amirpour N. The immunoregulatory and neuroprotective effects of human adipose derived stem cells overexpressing IL-11 and IL-13 in the experimental autoimmune encephalomyelitis mice. Int Immunopharmacol. 2020 Oct;87:106808. doi: 10.1016/j.intimp.2020.106808. Epub 2020 Jul 18. PMID: 32693359.
Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Novel Cell-Free Therapy
Xingcai Zhang, Lifang Ye, Wan Tang, Yiqin Ji, Li Zheng, Yijun Chen, Qidong Ge & Changshun Huang. (2022) Wnt/β-Catenin Participates in the Repair of Acute Respiratory Distress Syndrome-Associated Early Pulmonary Fibrosis via Mesenchymal Stem Cell Microvesicles. Drug Design, Development and Therapy 16, pages 237-247.