Mehmet Ozansoy
[email protected]Mehmet Ozansoy is a molecular biologist working in the field of neuroscience.
Dr. Ozansoy received his BSc., MSc and Ph.D. degrees from Boğaziçi University, Department of Molecular Biology and Genetics. During his graduate study he has worked in University College London (UCL), Rita Lila Weston Institute of Neurological Studies, Johns Hopkins University, Department of Neuroscience and Neurogenetics and Paris Salpetriere Hospital, INSERM Department of Neurogenetics. He has also worked as a post doctoral researcher in Neurodegeneration Research Laboratory (NDAL) led by Prof. Dr. A. Nazlı Başak.
Dr. Ozansoy focuses primarily on neurodegenerative disorders such as Alzheimer’s Disease, Parkinson’s Disease and ALS. Dr. Ozansoy’s group is specifically generating in vitro models of these disorders and the roles of regulatory RNAs in the molecular/cellular mechanisms of them.
They have also research projects related with the clinical staging of the neurodegenerative disorders and potential biomarkers.
In addition to that, Dr Ozansoy is interested and working in the field of neuro-oncology. Screening and evaluating of drug candidates in the context of gliomas.
Recently he has started to focus on the neural correlates of time perception and its disruption in the context of several neuropsychiatric disorders.
Selected Publications;
The Potential Role of Boron in the Modulation of Gut Microbiota Composition: An In Vivo Pilot Study
Sentürk NB, Kasapoglu B, Sahin E, Ozcan O, Ozansoy M, Ozansoy MB, Siyah P, Sezerman U, Sahin F. The Potential Role of Boron in the Modulation of Gut Microbiota Composition: An In Vivo Pilot Study. Pharmaceuticals (Basel). 2024 Oct 6;17(10):1334. doi: 10.3390/ph17101334. PMID: 39458975; PMCID: PMC11510266.
Exosomes: A missing link between chronic systemic inflammation and Alzheimer's disease?
Ozansoy M, Mikati H, Velioglu VA, Yulug B, “Exosomes: A missing link between chronic systemic inflammation and Alzheimer's disease?”, Biomed Pharmacother 2023 Jan 13;159:114161. doi: 10.1016/j.biopha.2022.114161.
Two boron-containing compounds affect the cellular viability of SH-SY5Y cells in an in vitro amyloid-beta toxicity model
Ozansoy M, Altıntaş MÖ, Ozansoy MB, Günay N, Kılıç E, Kılıç Ü, “Two boron-containing compounds affect the cellular viability of SH-SY5Y cells in an in vitro amyloid-beta toxicity model”, Turkish Journal of Biology, 2020, doi: 10.3906/biy-2001-22
Melatonin Affects the Release of Exosomes and Tau-Content in In Vitro Amyloid-Beta Toxicity Model
Ozansoy M, Ozansoy MB, Yulug B, Cankaya S, Kilic E, Goktekin S, Kilic U, “Melatonin Affects the Release of Exosomes and Tau-Content in In Vitro Amyloid-Beta Toxicity Model”, J Clin Neurosci, 2020, 73: 237-244, doi: 10.1016/j.jocn.2019.11.046
The association between HbA1c levels, olfactory memory and cognition in normal, pre-diabetic and diabetic persons
Yulug B, Saatci O, Isiklar A, Kilic U, Hanoglu L, Ozansoy M, Cankaya S, Cankaya B, Kilic E, “The association between HbA1c levels, olfactory memory and cognition in normal, pre-diabetic and diabetic persons” Endocr Metab Immune Disord Drug Targets. 2020 20(2): 198-212, doi: 10.2174/1871530319666190614121738
Squalene Activates AKT/mTOR Pathway Against Cisplatin-Induced Kidney Damage
Şakul AA, Ozansoy M, Elibol B, Ayla Ş, Günal MY, Yozgat Y, Başağa SH, Şahin K, Kazancıoğlu R, Kılıç Ü, “Squalene Activates AKT/mTOR Pathway Against Cisplatin-Induced Kidney Damage”, Turkish Journal of Biology 2019 43: 179-188. doi:10.3906/biy-1902-77.
Minocycline increases in vitro cortical neuronal cell survival after laser axotomy
Yuluğ B, Ozansoy M, Alökten M, Çetin-Ozansoy MB, Çankaya Ş, Hanoğlu L, Kılıç Ü, Kılıç E. “Minocycline increases in vitro cortical neuronal cell survival after laser axotomy”. Curr Clin Pharmacol. Feb 25, 2019. doi: 10.2174/1574884714666190226093119
Neonatal Neurodegeneration in Alzheimer's Disease Transgenic Mouse Model
Mazi AR, Arzuman AS, Gurel B, Sahin B, Tuzuner MB, Ozansoy M, Baykal AT. Neonatal Neurodegeneration in Alzheimer's Disease Transgenic Mouse Model. J Alzheimers Dis Rep. 2018 Apr 12;2(1):79-91. doi: 10.3233/ADR-170049. PMID: 30480251; PMCID: PMC6159732.
Early Stage Alterations in CA1 Extracellular Region Proteins Indicate Dysregulation of IL6 and Iron Homeostasis in the 5XFAD Alzheimer’s Disease Mouse Model
Gurel B, Cansev M, Sevinc C, Kelestemur S, Ocalan B, Cakir A, Aydin S, Kahveci N, Ozansoy M, Taskapilioglu O, Ulus IH, Başar MK, Sahin B, Tuzuner MB, Baykal AT, “Early Stage Alterations in CA1 Extracellular Region Proteins Indicate Dysregulation of IL6 and Iron Homeostasis in the 5XFAD Alzheimer’s Disease Mouse Model”, J. Alzheimers Dis., Vol: 61(4), pp:1399-1410, 2018.
The Therapeutic Role of Rifampicin in Alzheimer’s Disease
Yulug B, Hanoglu L, Ozansoy M, Isik D, Kilic U, Kilic E, Schabitz WR, “The Therapeutic Role of Rifampicin in Alzheimer’s Disease”, Psychiatry Clin. Neurosci. Jan. 8, 2018.
The Central Theme of Parkinson’s Disease: α-Synuclein
M. Ozansoy, A.N. Başak, “The Central Theme of Parkinson’s Disease: α-Synuclein”, Molecular Neurobiology, 47(2): 460-465, 2013.
Related Posts;
Ekim 11, 2024
Assist. Prof. Mehmet Ozansoy from Istanbul Medipol University is going to be at SABITALKS on October 16, 2024 at 14:00. The event will take place in person. You […]