New Insights / Bidirectional coupling of neuronal Ca2+ and nitric oxide signals visualized by a dual biosensor

Understanding how cells process and integrate multiple signaling pathways is essential for decoding complex biological systems.

A new study by SABITA researchers, led by Asel Aydeğer from the research group of Assoc. Prof. Emrah Eroğlu and published in Redox Biology (Q1), provides important insights into this challenge. By developing a dual biosensor system, the team makes it possible to simultaneously visualize calcium and nitric oxide dynamics within living hippocampal neurons. This approach reveals that these signals do not operate in isolation, but interact in a tightly coordinated and bidirectional manner.

The findings shed light on the fundamental logic of cellular communication, demonstrating how neurons integrate multiple signals to produce precise responses. By turning previously invisible interactions into observable processes, the study opens new avenues for investigating complex biological systems in both health and disease.

Explore the full study in Redox Biology: https://www.sciencedirect.com/science/article/pii/S2213231726000923