Esra Ayan
Esra Ayan completed her Bachelor of Science degree in Biological Education at Selçuk University. She pursued her Master of Science degree in Biochemistry and Molecular Biology at Acıbadem University, where her research focused on investigating the gut-brain axis in Alzheimer's Disease using metaproteomics approaches. Subsequently, she earned her Ph.D. in Molecular Biology and Genetics from Koç University, with a research emphasis on high-throughput recombinant protein production and crystallization, as well as understanding the dynamic and kinetic mechanisms of oligomeric proteins' hierarchy through X-ray crystallography. Currently, at Medipol SABITA, Esra's research is centered on the structural neuroscience and neuroproteomics of insulin resistance in Alzheimer's Disease.Selected Publications;
X-ray Crystallographic and Hydrogen Deuterium Exchange Studies Confirm Alternate Kinetic Models for Homolog Insulin Monomers
Ayan, E., Turk, M., Tatli, O., Telek, E., Dingiloglu, B., Dinler Doganay, G., & Demirci, H. (2024). X-ray Crystallographic and Hydrogen Deuterium Exchange Studies Confirm Alternate Kinetic Models for Homolog Insulin Monomers. bioRxiv, 2024-04.
Bridging the Gap between Gut Microbiota and Alzheimer’s Disease: A Metaproteomic Approach for Biomarker Discovery in Transgenic Mice
Ayan, E., DeMirci, H., Serdar, M. A., Palermo, F., & Baykal, A. T. (2023). Bridging the Gap between Gut Microbiota and Alzheimer’s Disease: A Metaproteomic Approach for Biomarker Discovery in Transgenic Mice. International Journal of Molecular Sciences, 24(16), 12819.
A brief atlas of insulin
Ayan, E., & DeMirci, H. (2023). A brief atlas of insulin. Current Diabetes Reviews, 19(6), 18-79.
Comparative Study of High-resolution LysB29 (Nε-myristoyl) des (B30) Insulin Structures Display Novel Dynamic Causal Interrelations in Monomeric-Dimeric Motions
Ayan, E., Destan, E., Kepceoglu, A., Ciftci, H. I., Kati, A., & DeMirci, H. (2023). Comparative Study of High-resolution LysB29 (Nε-myristoyl) des (B30) Insulin Structures Display Novel Dynamic Causal Interrelations in Monomeric-Dimeric Motions. Crystals, 13(4), 648.
Cooperative allostery and structural dynamics of streptavidin at cryogenic-and ambient-temperature
Ayan, E., Yuksel, B., Destan, E., Ertem, F. B., Yildirim, G., Eren, M., ... & DeMirci, H. (2022). Cooperative allostery and structural dynamics of streptavidin at cryogenic-and ambient-temperature. Communications biology, 5(1), 73.
Cryogenic X-ray crystallographic studies of biomacromolecules at Turkish Light Source" Turkish DeLight"
Atalay, N., Akcan, E. K., Gül, M., Ayan, E., Destan, E., KUZUCU, F. B. E., ... & Demirci, H. (2023). Cryogenic X-ray crystallographic studies of biomacromolecules at Turkish Light Source" Turkish DeLight". Turkish Journal of Biology, 47(1), 1-13.
Rapid and efficient ambient temperature X-ray crystal structure determination at Turkish Light Source
Gul, M., Ayan, E., Destan, E., Johnson, J. A., Shafiei, A., Kepceoğlu, A., ... & DeMi̇rci̇, H. (2023). Rapid and efficient ambient temperature X-ray crystal structure determination at Turkish Light Source. Scientific reports, 13(1), 8123.
Identification of New L-Heptanoylphosphatidyl Inositol Pentakisphosphate Derivatives Targeting the Interaction with HIV-1 Gag by Molecular Modelling Studies
Ciftci, H., Sever, B., Ayan, E., Can, M., DeMirci, H., Otsuka, M., ... & Fujita, M. (2022). Identification of New L-Heptanoylphosphatidyl Inositol Pentakisphosphate Derivatives Targeting the Interaction with HIV-1 Gag by Molecular Modelling Studies. Pharmaceuticals, 15(10), 1255.
Near-physiological-temperature serial femtosecond X-ray crystallography reveals novel conformations of SARS-CoV-2 main protease active site for improved drug repurposing
Durdagi, S., Dag, C., Dogan, B., Yigin, M., Avsar, T., Buyukdag, C., ... & DeMirci, H. (2020). Near-physiological-temperature serial femtosecond X-ray crystallography reveals novel conformations of SARS-CoV-2 main protease active site for improved drug repurposing. bioRxiv, 2020-09.
Structural insight into host plasma membrane association and assembly of HIV-1 matrix protein
Ciftci, H., Tateishi, H., Koiwai, K., Koga, R., Anraku, K., Monde, K., ... & DeMirci, H. (2021). Structural insight into host plasma membrane association and assembly of HIV-1 matrix protein. Scientific reports, 11(1), 15819.
Structural insights into bifunctional thaumarchaeal crotonyl-CoA hydratase and 3-hydroxypropionyl-CoA dehydratase from Nitrosopumilus maritimus
Destan, E., Yuksel, B., Tolar, B. B., Ayan, E., Deutsch, S., Yoshikuni, Y., ... & DeMirci, H. (2021). Structural insights into bifunctional thaumarchaeal crotonyl-CoA hydratase and 3-hydroxypropionyl-CoA dehydratase from Nitrosopumilus maritimus. Scientific reports, 11(1), 22849.
Case study of high-throughput drug screening and remote data collection for SARS-CoV-2 main protease by using serial femtosecond X-ray crystallography
Guven, O., Gul, M., Ayan, E., Johnson, J. A., Cakilkaya, B., Usta, G., ... & DeMirci, H. (2021). Case study of high-throughput drug screening and remote data collection for SARS-CoV-2 main protease by using serial femtosecond X-ray crystallography. Crystals, 11(12), 1579.
Protocol for structure determination of SARS-CoV-2 main protease at near-physiological-temperature by serial femtosecond crystallography
Ertem, F. B., Guven, O., Buyukdag, C., Gocenler, O., Ayan, E., Yuksel, B., ... & DeMirci, H. (2022). Protocol for structure determination of SARS-CoV-2 main protease at near-physiological-temperature by serial femtosecond crystallography. STAR protocols, 3(1), 101158.
4D Crystallography Captures Transient IF1-Ribosome Dynamics in Translation Initiation
Yapici, I., Dao, E. H., Yokoi, S., Destan, E., Ayan, E., Shafiei Kamel, A., ... & DeMirci, H. (2023). 4D Crystallography Captures Transient IF1-Ribosome Dynamics in Translation Initiation. bioRxiv, 2023-10.
Ambient Temperature Bacterial Large Ribosomal Subunit Structure Enabled by Serial Femtosecond X-ray Crystallography
Tosun, B., Rao, Y., Destan, E., Dao, E. H., Ertem, F. B., Yilmaz, M., ... & DeMirci, H. (2023). Ambient Temperature Bacterial Large Ribosomal Subunit Structure Enabled by Serial Femtosecond X-ray Crystallography. bioRxiv, 2023-10.