Assoc. Prof. Özge Şensoy
[email protected]Ozge Sensoy received her B.S. degree in Molecular Biology and Genetics and Chemistry (double major) from Istanbul Technical University. She earned her Ph.D. degree in the department of Computational Science and Engineering at Koc University where she focused on understanding structural and thermodynamic properties of peptide-based nanomaterials. Upon completion of her graduate studies, she went to Weill Cornell Medical College (USA) to conduct her postdoctoral studies in 2011. During her studies, she focused on understanding structural and dynamic properties of proteins involved in G protein-coupled receptor mediated signaling to design therapeutic molecules that can initiate a certain signaling pathway while masking the others. Dr. Sensoy is currently holding a faculty position in the Department of Biomedical Engineering in the School of Engineering and Natural Sciences. Her main research interests are targeted antibiotic resistance, RAS proteins, biased signaling, GPCR, Arrestin, G protein, posttranslational modifications, and allostery.
Selected Publications;
This is the 1st itemSynthesis, Structural Investigations, DNA/BSA Interactions, Molecular Docking Studies, and Anticancer Activity of a New 1,4-Disubstituted 1,2,3-Triazole Derivative
Göktürk T, Sakallı Çetin E, Hökelek T, Pekel H, Şensoy Ö, Aksu EN, Güp R. Synthesis, Structural Investigations, DNA/BSA Interactions, Molecular Docking Studies, and Anticancer Activity of a New 1,4-Disubstituted 1,2,3-Triazole Derivative. ACS Omega. 2023 Aug 25;8(35):31839-31856. doi: 10.1021/acsomega.3c03355. PMID: 37692230; PMCID: PMC10483525.
Nonlocal Effects of Antibiotic-Resistance-Causing Mutations Reveal an Alternative Region for Targeting on FtsW-Penicillin-Binding Protein 3 Complex of Haemophilus influenzae
Alhamwi AB, Atilgan C, Sensoy O. Nonlocal Effects of Antibiotic-Resistance-Causing Mutations Reveal an Alternative Region for Targeting on FtsW-Penicillin-Binding Protein 3 Complex of Haemophilus influenzae. J Chem Inf Model. 2023 May 22;63(10):3094-3104. doi: 10.1021/acs.jcim.3c00127. Epub 2023 May 4. PMID: 37141552.
Inhibition of mutant RAS-RAF interaction by mimicking structural and dynamic properties of phosphorylated RAS
Ilter M, Kasmer R, Jalalypour F, Atilgan C, Topcu O, Karakas N, Sensoy O. Inhibition of mutant RAS-RAF interaction by mimicking structural and dynamic properties of phosphorylated RAS. Elife. 2022 Dec 2;11:e79747. doi: 10.7554/eLife.79747. PMID: 36458814; PMCID: PMC9762712.
Mechanistic Insight Into Impact of Phosphorylation on The Enzymatic Steps of Farnesyltransferase
Pekel H, Guzel M, Sensoy O. Mechanistic insight into impact of phosphorylation on the enzymatic steps of farnesyltransferase. Protein Sci. 2022 Oct;31(10):e4414. doi: 10.1002/pro.4414. PMID: 36173156; PMCID: PMC9601885.
Inhibition of SARS-CoV-2 Main Protease: A Repurposing Study that Targets The Dimer Interface of The Protein
Pekel H, Ilter M, Sensoy O. Inhibition of SARS-CoV-2 main protease: a repurposing study that targets the dimer interface of the protein. J Biomol Struct Dyn. 2022 Sep;40(15):7167-7182. doi: 10.1080/07391102.2021.1910571. Epub 2021 Apr 13. PMID: 33847241; PMCID: PMC8054500.
Experimental and Computational Investigation of Clustering Behavior of Cyclodextrin-Perfluorocarbon Inclusion Complexes as Effective Histotripsy Agents
Kaymaz B, Mustafa W, Hall S, Vlaisavljevich E, Sensoy O, Yuksel Durmaz Y. Experimental and Computational Investigation of Clustering Behavior of Cyclodextrin-Perfluorocarbon Inclusion Complexes as Effective Histotripsy Agents. Mol Pharm. 2022 Aug 1;19(8):2907-2921. doi: 10.1021/acs.molpharmaceut.2c00268. Epub 2022 Jul 15. PMID: 35839291.
Hexokinase 1b is a novel target for Non–small-cell lung cancer
Hexokinase 1b is a novel target for Non–small-cell lung cancer.Yasemin Yozgat, Emre Karakoc, Ozgur Sahin, Seyma Cimen, Wael M. Rabeh, Mehmet Serif Aydin, Adil Mardinoglu, Ihsan Gursel, Asli Cakir, Ozge Sensoy, Ekrem M. Ozdemir, Yusuf Bayrak, Mehmet Z. Gunluoglu, Ozge Saatci, Javaid Jabbar, Juliana C. Ferreira, Melike Dinccelik Aslan, Muzaffer Yildirim, Samman Mansoor, Bilal E. Kerman, Zeynep Aladag, Woonghee Kim, Muhammad Arif, Emre Vatandaslar, Olgu E. Tok, Zeynep Dogru, Aslı G. O. Demir, Tugce Canavar Yildirim, İhsan Yozgat, Serif Senturk, Gurkan Ozturk, Murat Alper Cevher
bioRxiv 2022.06.27.497447; doi: https://doi.org/10.1101/2022.06.27.497447
Mechanistic Insight Into Impact of Phosphorylation on The Enzymatic Steps of Farnesyltransferase
Pekel H, Guzel M, Sensoy O. Mechanistic insight into impact of phosphorylation on the enzymatic steps of farnesyltransferase. Protein Sci. 2022 Oct;31(10):e4414. doi: 10.1002/pro.4414. PMID: 36173156; PMCID: PMC9601885.
Insight Into Impact of High Resistance-Causing Mutations on Penicillin Binding Protein 3 of h. Influenzae Suggests an Alternative Approach for Combating Antibiotic Resistance
Alhamwi, A. b., Atılgan, C., & Sensoy, O. (2022). Insight into impact of high resistance-causing mutations on penicillin binding protein 3 of h. influenzae suggests an alternative approach for combating antibiotic resistance. 2057. https://hibit2022.ims.metu.edu.tr/
Mechanistic Insight Into The Impact of A Bivalent Ligand on The Structure and Dynamics of A GPCR Oligomer
Mansoor S, Kayık G, Durdagi S, Sensoy O. Mechanistic insight into the impact of a bivalent ligand on the structure and dynamics of a GPCR oligomer. Comput Struct Biotechnol J. 2022 Feb 4;20:925-936. doi: 10.1016/j.csbj.2022.01.016. PMID: 35242285; PMCID: PMC8861583.
Dimethyl Sulfoxide Reduces The Stability But Enhances Catalytic Activity of The Main SARS‐CoV‐2 Protease 3CLpro
Ferreira JC, Fadl S, Ilter M, Pekel H, Rezgui R, Sensoy O, Rabeh WM. Dimethyl sulfoxide reduces the stability but enhances catalytic activity of the main SARS-CoV-2 protease 3CLpro. FASEB J. 2021 Aug;35(8):e21774. doi: 10.1096/fj.202100994. PMID: 34324734; PMCID: PMC8441638.
Heterobivalent Ligands Suitable for use in The Treatment of Parkinson's Disease
Prasad K, de Vries EFJ, Elsinga PH, Dierckx RAJO, van Waarde A. Allosteric Interactions between Adenosine A2A and Dopamine D2 Receptors in Heteromeric Complexes: Biochemical and Pharmacological Characteristics, and Opportunities for PET Imaging. Int J Mol Sci. 2021 Feb 9;22(4):1719. doi: 10.3390/ijms22041719. PMID: 33572077; PMCID: PMC7915359.
Linker Residues Regulate the Activity and Stability of Hexokinase 2, A Promising Anticancer Target
Ferreira JC, Khrbtli AR, Shetler CL, Mansoor S, Ali L, Sensoy O, Rabeh WM. Linker residues regulate the activity and stability of hexokinase 2, a promising anticancer target. J Biol Chem. 2021 Jan-Jun;296:100071. doi: 10.1074/jbc.RA120.015293. Epub 2020 Nov 24. PMID: 33187984; PMCID: PMC7949118.
In Silico Analysis of a Highly Mutated Gene in Cancer Provides Insight into Abnormal mRNA Splicing: Splicing Factor 3B Subunit 1K 700 E Mutant
Samy A, Suzek BE, Ozdemir MK, Sensoy O. In Silico Analysis of a Highly Mutated Gene in Cancer Provides Insight into Abnormal mRNA Splicing: Splicing Factor 3B Subunit 1K700E Mutant. Biomolecules. 2020 Apr 28;10(5):680. doi: 10.3390/biom10050680. PMID: 32354150; PMCID: PMC7277358.
Perturb–Scan–Pull: A Novel Method Facilitating Conformational Transitions in Proteins
Samy A, Suzek BE, Ozdemir MK, Sensoy O. In Silico Analysis of a Highly Mutated Gene in Cancer Provides Insight into Abnormal mRNA Splicing: Splicing Factor 3B Subunit 1K700E Mutant. Biomolecules. 2020 Apr 28;10(5):680. doi: 10.3390/biom10050680. PMID: 32354150; PMCID: PMC7277358.
Catalytically Competent Non-transforming H-RASG12P Mutant Provides Insight into Molecular Switch Function and GAP-independent GTPase Activity of RAS
Ilter M, Sensoy O. Catalytically Competent Non-transforming H-RASG12P Mutant Provides Insight into Molecular Switch Function and GAP-independent GTPase Activity of RAS. Sci Rep. 2019 Jul 29;9(1):10967. doi: 10.1038/s41598-019-47481-1. PMID: 31358828; PMCID: PMC6662853.
Perturbation-Response Scanning Reveals Key Residues for Allosteric Control in Hsp70
Penkler D, Sensoy Ö, Atilgan C, Tastan Bishop Ö. Perturbation-Response Scanning Reveals Key Residues for Allosteric Control in Hsp70. J Chem Inf Model. 2017 Jun 26;57(6):1359-1374. doi: 10.1021/acs.jcim.6b00775. Epub 2017 Jun 12. PMID: 28505454.
A mechanistic role of Helix 8 in GPCRs: Computational modeling of the dopamine D2 receptor interaction with the GIPC1-PDZ-domain
Sensoy O, Weinstein H. A mechanistic role of Helix 8 in GPCRs: Computational modeling of the dopamine D2 receptor interaction with the GIPC1-PDZ-domain. Biochim Biophys Acta. 2015 Apr;1848(4):976-83. doi: 10.1016/j.bbamem.2014.12.002. Epub 2015 Jan 12. PMID: 25592838; PMCID: PMC4336197.
Self-assembling multidomain peptide fibers with aromatic cores
Bakota EL, Sensoy O, Ozgur B, Sayar M, Hartgerink JD. Self-assembling multidomain peptide fibers with aromatic cores. Biomacromolecules. 2013 May 13;14(5):1370-8. doi: 10.1021/bm4000019. Epub 2013 Mar 29. PMID: 23480446; PMCID: PMC3654057.
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