Assoc. Prof. Nihal Karakaş
[email protected]Nihal Karakaş received her bachelor’s degree in Science Education at İstanbul University in 2006 . Then, she studied on neural induction of mesenchymal stem cells and hold MSc. degree in Molecular Biology in 2009. During her graduate education, she joined “Adult Cell Therapy Group” and experienced cellular therapy approaches (especially worked on hematopoietic stem cells) at Center for Regenerative Medicine, Edinburgh University. She then started a Ph.D. program in Neuroscience at Health Sciences Institute at Istanbul University in 2009. After completing her courses, she joined Molecular Neurotherapy and Imaging Laboratory (MNIL) at Massachusetts General Hospital, Harvard Medical School and worked on stem cell therapeutics for the tratment of glioblastoma brain tumor (2011-2014). Dr. Karakas's current interests mainly focus on the discovery of new diagnostic and therapeutic markers; therefore the development of targeted therapy approaches for especially malignant brain tumors. She leads goal oriented projects with international collaborations and holds several fundings. Recently, she works as an Assistant Professor at Istanbul Medipol University, School of Medicine and Principle Investigator at Regenerative and Restorative Medicine Research Center (REMER) since 2016.
Selected Publications;
Inhibition of mutant RAS-RAF interaction by mimicking structural and dynamic properties of phosphorylated RAS
Metehan Ilter, Ramazan Kaşmer, Farzaneh Jalalypour, Canan Atilgan, Ozan Topcu, Nihal Karakaş, Ozge Sensoy.Inhibition of mutant RAS-RAF interaction by mimicking structural and dynamic properties of phosphorylated RAS. bioRxiv 2022. 04.24.489309; doi: https://doi.org/10.1101/2022.04.24.489309
Potential of Novel Methyl Jasmonate Analogs as Anticancer Agents to Metabolically Target HK-2 Activity in Glioblastoma Cells
Uludağ D, Bay S, Sucu BO, Şavluğ İpek Ö, Mohr T, Güzel M and Karakaş N (2022) Potential of Novel Methyl Jasmonate Analogs as Anticancer Agents to Metabolically Target HK-2 Activity in Glioblastoma Cells. Front. Pharmacol. 13:828400. doi: 10.3389/fphar.2022.828400
Design and synthesis of novel caffeic acid phenethyl ester (CAPE) derivatives and their biological activity studies in glioblastoma multiforme (GBM) cancer cell lines
Sucu Bilgesu Onur, Koc Elif Beyza, Savlug Ipek Ozgecan,Mirat Afranur, Alma Furkan, Guzel Melike Aybala, Dogan Berna, Uludag Damla, Karakaş Nihal, Durdagi Serdar,Guzel Mustafa, Design and synthesis of novel caffeic acid phenethyl ester (CAPE) derivatives and their biological activity studies in glioblastoma multiforme (GBM) cancer cell lines. J Mol Graph Model, (2022);113:108160.
Mesenchymal Stem Cell-Based COVID-19 Therapy: Bioengineering Perspectives
Karakaş Nihal, Süleyman Üçüncüoğlu, Damla Uludağ, Birnur S. Karaoğlan, Khalid Shah, and Gürkan Öztürk. (2022). “Mesenchymal Stem Cell-Based COVID-19 Therapy: Bioengineering Perspectives” Cells 11, no. 3: 465. https://doi.org/10.3390/cells11030465
IL13 Fused Pseudomonas Exotoxin Targets Various Cancers In Vitro
Uludag Damla, Karakaş Nihal (2021). IL13 Fused Pseudomonas Exotoxin Targets Various Cancers In Vitro. Anticancer Research, 41(7), 3471-3480., Doi: 10.21873/anticanres.15134
Integrin a5b1 Mediated Cellular Reorganization in Human Mesenchymal Stem Cells During Neuronal Differentiation
Karakaş Nihal, Kılıç Ülkan (2021). Integrin a5b1 Mediated Cellular Reorganization in Human Mesenchymal Stem Cells During Neuronal Differentiation. In Vivo, 35(4), 2127-2134., Doi: 10.21873/invivo.12482
IL13Ra2 and EGFR targeted pseudomonas exotoxin potentiates the TRAIL mediated death of GBM cells
Karakaş Nihal, Stuckey Daniel, Lechtich Esther Revai, Shah Khalid (2021). IL13Ra2 and EGFR targeted pseudomonas exotoxin potentiates the TRAIL mediated death of GBM cells. International Journal of Molecular Medicine, 48(1), Doi: 10.3892/ijmm.2021.4978
Neurons from human mesenchymal stem cells display both spontaneous and stimuli responsive activity
Karakaş Nihal,Bay Sadık,Türkel Nezaket,Öztunç Nursah,Öncül Merve,BILGEN HÜLYA,Shah Khalid,ÖZTÜRK GÜRKAN (2020). Neurons from human mesenchymal stem cells display both spontaneous and stimuli responsive activity. PLOS ONE, 15(5), 228510
Synthesis of novel methyl jasmonate derivatives and evaluation of their biological activity in various cancer cell lines
SUCU BILGESU ONUR,Savlug Özgecan,ÖZDATLI SÜKRAN,YAZICI BÜSRA EMINE,KARAKAS NIHAL,GÜZEL MUSTAFA (2019). Synthesis of novel methyl jasmonate derivatives and evaluation of their biological activity in various cancer cell lines. Bioorganic Chemistry, 91, 103146, Doi: 10.1016/j.bioorg.2019.103146
DNA topoisomerase II As a molecular switch in Neural differentiation of mesenchymal stem cells
Isık Sevim,Zaim Merve,YILDIZ MEHMET TAHA,NEGIS YESIM,Kunduracı Tuba,KARAKAS NIHAL,Arıkan Gülsüm,ÇETIN GÜVEN (2015). DNA topoisomerase II As a molecular switch in Neural differentiation of mesenchymal stem cells. Annals of Hematology, 94(2), 307-318., Doi: 10.1007/s00277-014-2209-7
Engineering Toxin-Resistant Therapeutic Stem Cells to Treat Brain Tumors
Stuckey, D.W., Hingtgen, S.D., Karakas, N., Rich, B.E. and Shah, K. (2015), Engineering Toxin-Resistant Therapeutic Stem Cells to Treat Brain Tumors. Stem Cells, 33: 589-600. https://doi.org/10.1002/stem.1874
Comparison of long-term retinoic acidbased Neural induction methods of bone marrow human mesenchymal stem cells
Mammadov Büsra,KARAKAS NIHAL,Isık Sevim (2011). Comparison of long-term retinoic acidbased Neural induction methods of bone marrow human mesenchymal stem cells. In Vitro Cellular Developmental Biology – Animal, 47(7), 484-491., Doi: 10.1007/s11626-011-9425-4
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