Deniz Atasoy
Deniz Atasoy received his B.S. in Molecular Biology and Genetics from Bilkent University Ankara/Turkey and his Ph.D. in Neuroscience from the University of Texas Southwesten Medical Center at Dallas. He moved to Ashburn, Virginia for his postdoctoral studies at Janelia Research Campus where he studied neurobiological basis of appetite regulation. Between 2014-2018 he worked as a faculty member at Medipol University . Since September 2018, he has been a member of the Department of Pharmacology at the University of Iowa.Selected Publications;
FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit
Flippo KH, Trammell SAJ, Gillum MP, Aklan I, Perez MB, Yavuz Y, Smith NK, Jensen-Cody SO, Zhou B, Claflin KE, Beierschmitt A, Fink-Jensen A, Knop FK, Palmour RM, Grueter BA, Atasoy D, Potthoff MJ. FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit. Cell Metab. 2022 Feb 1;34(2):317-328.e6. doi: 10.1016/j.cmet.2021.12.024. PubMed PMID: 35108517; PubMed Central PMCID: PMC9093612.
Presynaptic store-operated Ca2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress
Chanaday NL, Nosyreva E, Shin OH, Zhang H, Aklan I, Atasoy D, Bezprozvanny I, Kavalali ET. Presynaptic store-operated Ca2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress. Neuron. 2021 Apr 21;109(8):1314-1332.e5. doi: 10.1016/j.neuron.2021.02.023. Epub 2021 Mar 11. PubMed PMID: 33711258; PubMed Central PMCID: PMC8068669.
FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake
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Jensen-Cody SO, Flippo KH, Claflin KE, Yavuz Y, Sapouckey SA, Walters GC, Usachev YM, Atasoy D, Gillum MP, Potthoff MJ. FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake. Cell Metab. 2020 Aug 4;32(2):273-286.e6. doi: 10.1016/j.cmet.2020.06.008. Epub 2020 Jul 7. PubMed PMID: 32640184; PubMed Central PMCID: PMC7734879.
NTS Catecholamine Neurons Mediate Hypoglycemic Hunger via Medial Hypothalamic Feeding Pathways
Aklan I, Sayar Atasoy N, Yavuz Y, Ates T, Coban I, Koksalar F, Filiz G, Topcu IC, Oncul M, Dilsiz P, Cebecioglu U, Alp MI, Yilmaz B, Davis DR, Hajdukiewicz K, Saito K, Konopka W, Cui H, Atasoy D. NTS Catecholamine Neurons Mediate Hypoglycemic Hunger via Medial Hypothalamic Feeding Pathways. Cell Metab. 2020 Feb 4;31(2):313-326.e5. doi: 10.1016/j.cmet.2019.11.016. Epub 2019 Dec 12. PubMed PMID: 31839488; PubMed Central PMCID: PMC9017597.
MCH Neuron Activity Is Sufficient for Reward and Reinforces Feeding
Dilsiz P, Aklan I, Sayar Atasoy N, Yavuz Y, Filiz G, Koksalar F, Ates T, Oncul M, Coban I, Ates Oz E, Cebecioglu U, Alp MI, Yilmaz B, Atasoy D. MCH Neuron Activity Is Sufficient for Reward and Reinforces Feeding. Neuroendocrinology. 2020;110(3-4):258-270. doi: 10.1159/000501234. Epub 2019 Jun 3. PubMed PMID: 31154452.
Inactivation of Magel2 suppresses oxytocin neurons through synaptic excitation-inhibition imbalance
Ates T, Oncul M, Dilsiz P, Topcu IC, Civas CC, Alp MI, Aklan I, Ates Oz E, Yavuz Y, Yilmaz B, Sayar Atasoy N, Atasoy D. Inactivation of Magel2 suppresses oxytocin neurons through synaptic excitation-inhibition imbalance. Neurobiol Dis. 2019 Jan;121:58-64. doi: 10.1016/j.nbd.2018.09.017. Epub 2018 Sep 19. PubMed PMID: 30240706.
Impaired melanocortin pathway function in Prader-Willi Syndrome gene-Magel2 deficient mice
Oncul M., Dilsiz P., Ates Oz E., Ates T., Aklan I., Celik E., Sayar Atasoy N., Atasoy D. Impaired melanocortin pathway function in Prader-Willi Syndrome gene-Magel2 deficient mice. Human Molecular Genetics 2018 Sep 15;27(18):3129-3136.
Chemogenetic tools for causal cellular and neuronal biology
Sternson S.M., Atasoy D., Chemogenetic tools for causal cellular and neuronal biology., Physiological Reviews 2018 Jan 1;98(1):391-418
An Emerging Technology Framework for the Neurobiology of Appetite
Sternson S.M., Atasoy D., Betley N., Henry F.E., Xu S. An Emerging Technology Framework for the Neurobiology of Appetite. Cell Metab. 2016 Feb; 23
A genetically specified connectomics approach applied to long-range feeding regulatory circuits
Atasoy D., Betley N., Scheffer L., Wei-Ping L., Su H., Sertel S.M., Simpson J.H., Fetter R., Sternson S.M. A genetically specified connectomics approach applied to long-range feeding regulatory circuits. Nature Neurosci. 2014 Dec;17(12):1830-9.
AGRP neuron circuits that regulate appetite.
Sternson S.M., Atasoy D. AGRP neuron circuits that regulate appetite. Neuroendocrinology 2014;100(2-3):95-102.
Deconstruction of a neural circuit for hunger
Atasoy D., Betley N., Su H., Sternson S.M. Deconstruction of a neural circuit for hunger. Nature 2012 Aug 9;488(7410):172-7.
Chemical and genetic engineering of selective ligand-ion channel interactions
Magnus CJ, Lee PH, Atasoy D, Su HH, Looger LL, Sternson SM. Chemical and genetic engineering of selective ion channel-ligand interactions. Science. 2011 Sep 2;333(6047):1292-6. doi: 10.1126/science.1206606. PMID: 21885782; PMCID: PMC3210548.
Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop
Yang Y., Atasoy D., Su H., Sternson S.M. Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop. Cell 2011 Sep 16;146(6):992-1003
AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training
Aponte Y., Atasoy D., Sternson S.M. AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training. Nature Neurosci. 2011 Mar;14(3):351-5