Despite the tremendous efforts to find a reasonable potent and efficacious drug candidate for the treatment of COVID-19, there is not a magic drug to cure the symptoms of this deadly disease. This study aims to give some information about natural compounds against SARS-CoV-2 and their ethnopharmacology, and the possible antiviral mechanism of especially plant secondary metabolites. Nowadays, although several NCEs were approved for the treatment of COVID-19 or to ease the symptoms, most of these new medicines seem to eventually be less effective in large populations. Moreover, it is imperative to use prophylactic agents and natural remedies to prevent infections as well as boost the immune system. When we look at the epidemiological and geographical movement of viral infections, it is obvious that the countries that follow naturopathic/homeopathic treatment options seem to recover faster than the other countries. Thus, it is extremely important to identify what natural treatment recipe works for certain households. For methodology, Web of Science, Sci-Finder, Google Scholar, Science Direct, Scopus, TUBIVES, CITES, and other databases were used as initial origins to look for related articles and apply search terms. In this review, many medicinal and aromatic plants, natural products, and commercial compounds were screened against SARS-CoV-2. Furthermore, it gives details about these compounds and related medicinal and aromatic plants. Also, this comprehensive review sheds light on current natural treatment options reported in the literature and the future projections to halt this deadly disease via natural medicines.