Prof. Dr. Ertuğrul Kılıç
Ertuğrul Kılıç graduated from Ankara University Faculty of Veterinary Medicine in 1994. He received his first PhD degree in 1999 from the Faculty of Medicine in the field of medicine physiology, Fırat Universty (Turkey) and second PhD from Tübingen University (Germany) in Cellular Biology. In the years of 1997-2008, he was at the Max-Planck Institute for experimental Neurology (Cologne, Germany), Department of Neurologies of Tübingen (Germany), Göttingen (Germany) and Zurich (Switzerland). Following, he started to work at the University of Yeditepe, Istanbul until 2013. He started to work at the Medipol University in 2013.He is a recipient of DAAD (Deutsche Academische Austausch Dienst; Germany), Franco Regli (National Neuroscience Price, Switzerland), JCI-TOYP (The Outstanding Young Person Award in Medicine Innovation, Turkey), EMBO-installation grant (European Molecular Biology Organization), and TUBA-GEBİP (Turkish Academy of Sciences, Turkey) grant and prices. He published more than 100 international research article and they were cited more than 5000. His h-index is 40.
Dr. Kılıç is currently holding a faculty position in Physiology Department of the School of Medicine.
Selected Publications;
Pinealectomy aggravates and melatonin administration attenuates brain damage in focal ischemia.
Kilic E, Özdemir YG, Bolay H, Keleştimur H, Dalkara T. Pinealectomy aggravates and melatonin administration attenuates brain damage in focal ischemia (1999) Journal of Cerebral Blood Flow and Metabolism, 19 (5), pp. 511-516.
Intravenous TAT-Bcl-XL is protective after middle cerebral artery occlusion in mice.
Kilic E, Dietz GPH, Hermann DM, Bähr M. Intravenous TAT-Bcl-XL is protective after middle cerebral artery occlusion in mice (2002) Annals of Neurology, 52 (5), pp. 617-622.
Brain-derived erythropoietin protects from focal cerebral ischemia by dual activation of ERK-1/-2 and Akt pathways.
Kilic E, Kilic Ü, Soliz J, Bassetti CL, Gassmaim M, Hermann DM. Brain-derived erythropoietin protects from focal cerebral ischemia by dual activation of ERK-1/-2 and Akt pathways (2005) FASEB Journal, 19 (14), pp. 2026-2028.
Inhibition of multidrug resistance transporter-1 facilitates neuroprotective therapies after focal cerebral ischemia.
Spudich A, Kilic E, Xing H, Kilic Ü, Rentsch KM, Wunderli-Allenspach H, Bassetti CL, Hermann DM. Inhibition of multidrug resistance transporter-1 facilitates neuroprotective therapies after focal cerebral ischemia (2006) Nature Neuroscience, 9 (4), pp. 487-488.
The phosphatidylinositol-3 kinase/Akt pathway mediates VEGF’s neuroprotective activity and induces blood brain barrier permeability after focal cerebral ischemia.
Kilic E, Kilic Ü, Wang Y, Bassetti CL, Marti HH, Hermann DM. The phosphatidylinositol-3 kinase/Akt pathway mediates VEGF’s neuroprotective activity and induces blood brain barrier permeability after focal cerebral ischemia (2006) FASEB Journal, 20 (8), pp. E307-E314.
Human vascular endothelial growth factor protects axotomized retinal ganglion cells in vivo by activating ERK-1/2 and Akt pathways.
Kilic Ü, Hermann DM, Kilic E, Järve, A, Guo, Z, Spudich, A, Bieber, K, Marti HH. Human vascular endothelial growth factor protects axotomized retinal ganglion cells in vivo by activating ERK-1/2 and Akt pathways (2006) Journal of Neuroscience, 26 (48), pp. 12439-12446.
ABCC1: A gateway for pharmacological compounds to the ischaemic brain.
Kilic E, Hermann DM, Spudich A, Kilic Ü, Rentsch KM, Vig R, Matter CM, Bassetti CL. ABCC1: A gateway for pharmacological compounds to the ischaemic brain (2008) Brain, 131 (10), pp. 2679-2689.
Role of Nogo-A in neuronal survival in the reperfused ischemic brain.
Kilic E, Elali A, Kilic U, Guo Z, Ugur M, Uslu U, Bassetti CL, Hermann DM. Role of Nogo-A in neuronal survival in the reperfused ischemic brain (2010) Journal of Cerebral Blood Flow and Metabolism, 30 (5), pp. 969-984.
HMG-CoA reductase inhibitior rosuvastatin improves abnormal brain electrical activity via mechanisms involving eNOS.
Seker FB, Kilic U; Ekimci N, Ethemoglu MS, Caglayan B, Demirci S, Dogan S, Oztezcan S, Sahin F, Yilmaz B, Kilic E. HMG-CoA reductase inhibitior rosuvastatin improves abnormal brain electrical activity via mechanisms involving eNOS. Neuroscience. 2015. 284: 349-359
HMG-CoA reductase inhibition promotes stroke recovery, perilesional tissue remodeling and contralesional pyramidal tract plasticity.
Kilic E, Reitmeir R, Kilic Ü, Caglayan AB, Beker MC, Kelestemur T, Ethemoglu S, Ozturk G, Hermann DM. HMG-CoA reductase inhibition promotes stroke recovery, perilesional tissue remodeling and contralesional pyramidal tract plasticity. Frontiers in Cellular Neuroscience. (in press) 2014.