Sarah Barakat
[email protected] / [email protected]Dr. Sarah Barakat began her academic career in dentistry, earning a Bachelor's degree from the University of Science and Technology in Yemen and a Master’s degree in Oral Pathology from the University of Malaya, where she developed an early interest in cellular mechanisms underlying disease. This interest led her to pursue a Ph.D. in Molecular Biology, Genetics, and Bioengineering at Sabancı University, where she specialized in the development and application of nanobodies as tools to investigate intracellular processes and molecular interactions.
In 2022, she joined the Research Institute for Health Sciences and Technologies (SABITA) at Istanbul Medipol University as a Senior Researcher. Her research focuses on multiomics data analysis, with particular expertise in proteomics and integrated approaches to investigate cellular mechanisms and molecular interactions.
Selected Publications;
Proteomic Data and Drug Implications for Cerebral Microvascular Endothelial Cells Under Varying Oxygen Levels
Barakat, S., Yang, F., Yelkenci, H.E. et al. Proteomic Data and Drug Implications for Cerebral Microvascular Endothelial Cells Under Varying Oxygen Levels. Sci Data 12, 989 (2025). https://doi.org/10.1038/s41597-025-05160-z
Dimerization Choice and Alternative Functions of ZBTB Transcription Factors
Sarah Barakat, Ege Ezen, İzem Devecioğlu, Melike Gezen, Sofia Piepoli, Batu Erman, Dimerization choice and alternative functions of ZBTB transcription factors, The FEBS Journal, 2023.
Sibling Rivalry Among the ZBTB Transcription Factor Family: Homo vs. Heterodimers
Sofia Piepoli, Sarah Barakat, Liyne Nogay , Büşra Şimşek , Umit Akkose , Hakan Taskiran , Nazife Tolay , Melike Gezen , Canberk Yarkın Yeşilada , Mustafa Tuncay , Ogun Adebali , Canan Atilgan , Batu Erman, Sibling rivalry among the ZBTB transcription factor family: homo vs. heterodimers, Life Science Alliance, 2022.
Nanobodies as Molecular Imaging Probes
Sarah Barakat, Melike Berksöz , Pegah Zahedimaram , Sofia Piepoli , Batu Erman, Nanobodies as molecular imaging probes, Free Radical Biology and Medicine, 2022.
Bioenergetic shift and proteomic signature induced by lentiviral-transduction of GFP-based biosensors
Sarah Barakat, Şeyma Çimen, Seyed Mohammad Miri, Emre Vatandaşlar, Hayriye Ecem Yelkenci, Alejandro San Martín, Mustafa Çağlar Beker, Kıvanç Kök, Gürkan Öztürk, Emrah Eroglu, Bioenergetic shift and proteomic signature induced by lentiviral-transduction of GFP-based biosensors, Redox Biology, 2024.
https://www.sciencedirect.com/science/article/pii/S221323172400394X
Development of an Oxygen-Insensitive Nrf2 Reporter Reveals Redox Regulation under Physiological Normoxia
Seyed Mohammad Miri, Büşra N Ata, Şeyma Çimen, Sarah Barakat, Asal Ghaffari Zaki, Joudi Armouch, Emre Vatandaşlar, Sven Vilain, Gürkan Öztürk, Emrah Eroğlu. Development of an Oxygen-Insensitive Nrf2 Reporter Reveals Redox Regulation under Physiological Normoxia. ACS Sens (2025)
https://pubmed.ncbi.nlm.nih.gov/40021628/