Tuba Akgül Çağlar
[email protected]Tuba Akgul Caglar received her B.S. degree in Biology from Marmara University. She subsequently earned her M.Sc. degree from the Institute of Biomedical Engineering at Boğaziçi University, where her research focused on the effects of early and delayed diode laser application on nerve regeneration in a mouse sciatic nerve crush model, using functional, electrophysiological, and histological analyses. During her master’s training, she was awarded an Erasmus/Internship Mobility grant and visited the German Primate Center in Göttingen, Germany, where she worked on signal processing in macaque models. She completed her Ph.D. in Neuroscience at İstanbul Medipol University under the supervision of Dr. Esra Çağavi. Her doctoral research aimed to elucidate the molecular and electrophysiological characteristics of heart-specific sensory neurons. To address this, she employed in vivo retrograde labeling, RNA sequencing, neuron–cardiomyocyte coculture models, and optogenetic stimulation approaches. Following the completion of her doctoral studies, Dr. Akgül Çağlar joined the laboratory of Dr. Emrah Eroğlu as a postdoctoral researcher at Sabancı University. During her postdoctoral training, she worked on multimodal live-cell imaging in neurons using genetically encoded biosensors and contributed to application of chemogenetic tools in the nervous system. She was awarded the TÜBİTAK 2218 National Postdoctoral Research Fellowship Program to investigate the functional role of nitric oxide in sensory information transmission. Dr. Akgül Çağlar is currently a Senior Researcher at İstanbul Medipol University under SABITA with research interests centered on elucidating nitric oxide signaling in the nervous system using advanced imaging strategies.
Selected Publications;
Effects of Early and Delayed laser application on nerve regeneration.
Akgul T, Gulsoy M, Gulcur HO, Effects of early and delayed laser application on nerve regeneration. Lasers Med Sci. 2014 Jan;29(1):351-7. doi: 10.1007/s10103-013-1355-9. Epub 2013 May 29.
Chemogenetic Manipulation of H2S with Spatiotemporal Precision.
Ghaffari Zaki, A.; Issa, H.; Miri, S. M.; Armouch, J.; Aydeger, A.; Yildirim, S.; Mete, R. Z.; Aljundi, O.; Vatandaşlar, E.; Akgul Caglar, T.; Çimen, Ş.; Yiğit, E. N.; Aydın, M. Ş.; Alp, M. İ.; Almammadov, T.; Vilain, S.; Eroglu, E. Chemogenetic Manipulation of H2S with Spatiotemporal Precision. Precis Chem 2026, 4 (1), 68–72. https://doi.org/10.1021/prechem.5c00189.
Visualizing Hydrogen Peroxide and Nitric Oxide Dynamics in Endothelial Cells Using Multispectral Imaging under Controlled Oxygen Conditions.
Altun, H. Y.; Secilmis, M.; Yang, F.; Akgul Caglar, T.; Vatandaslar, E.; Toy, M. F.; Vilain, S.; Mann, G. E.; Öztürk, G.; Eroglu, E. Visualizing Hydrogen Peroxide and Nitric Oxide Dynamics in Endothelial Cells Using Multispectral Imaging under Controlled Oxygen Conditions. Free Radic Biol Med 2024, 221, 89–97. https://doi.org/10.1016/j.freeradbiomed.2024.05.021.
Development of a Chemogenetic Approach to Manipulate Intracellular pH.
Ghaffari Zaki, A.; Miri, S. M.; Çimen, Ş.; Akgül Çağlar, T.; Yiğit, E. N.; Aydın, M. Ş.; Öztürk, G.; Eroglu, E. Development of a Chemogenetic Approach to Manipulate Intracellular pH. J Am Chem Soc 2023, 145 (22), 11899–11902. https://doi.org/10.1021/jacs.3c00703.
Nitric Oxide Biosensor Uncovers Diminished Ferrous Iron-Dependency of Cultured Cells Adapted to Physiological Oxygen Levels.
Sevimli, G.; Smith, M. J.; Caglar, T. A.; Bilir, Ş.; Secilmis, M.; Altun, H. Y.; Yigit, E. N.; Yang, F.; Keeley, T. P.; Malli, R.; Öztürk, G.; Mann, G. E.; Eroglu, E. Nitric Oxide Biosensor Uncovers Diminished Ferrous Iron-Dependency of Cultured Cells Adapted to Physiological Oxygen Levels. Redox Biol 2022, 53, 102319. https://doi.org/10.1016/j.redox.2022.102319.
Chemogenetic Approaches to Dissect the Role of H2O2 in Redox-Dependent Pathways Using Genetically Encoded Biosensors.
Ghaffari Zaki, A.; Erdoğan, Y. C.; Akgul Caglar, T.; Eroglu, E. Chemogenetic Approaches to Dissect the Role of H2O2 in Redox-Dependent Pathways Using Genetically Encoded Biosensors. Biochem Soc Trans 2022, 50 (1), 335–345. https://doi.org/10.1042/BST20210506.
Complexities of the Chemogenetic Toolkit: Differential mDAAO Activation by d-Amino Substrates and Subcellular Targeting.
Erdogan, Y. C.; Altun, H. Y.; Secilmis, M.; Ata, B. N.; Sevimli, G.; Cokluk, Z.; Zaki, A. G.; Sezen, S.; Akgul Caglar, T.; Sevgen, İ.; Steinhorn, B.; Ai, H.; Öztürk, G.; Belousov, V. V.; Michel, T.; Eroglu, E. Complexities of the Chemogenetic Toolkit: Differential mDAAO Activation by d-Amino Substrates and Subcellular Targeting. Free Radic Biol Med 2021, 177, 132–142. https://doi.org/10.1016/j.freeradbiomed.2021.10.023.
Defining Optimal Enzyme and Matrix Combination for Replating of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes at Different Levels of Maturity.
Koc, A.; Sahoglu Goktas, S.; Akgul Caglar, T.; Cagavi, E. Defining Optimal Enzyme and Matrix Combination for Replating of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes at Different Levels of Maturity. Exp Cell Res 2021, 403 (2), 112599. https://doi.org/10.1016/j.yexcr.2021.112599.
Evaluation of the Bilateral Cardiac Afferent Distribution at the Spinal and Vagal Ganglia by Retrograde Labeling.
Akgul Caglar, T.; Durdu, Z. B.; Turhan, M. U.; Gunal, M. Y.; Aydın, M. S.; Ozturk, G.; Cagavi, E. Evaluation of the Bilateral Cardiac Afferent Distribution at the Spinal and Vagal Ganglia by Retrograde Labeling. Brain Res 2021, 1751, 147201. https://doi.org/10.1016/j.brainres.2020.147201.
Zero-Valent Iron Nanoparticles Containing Nanofiber Scaffolds for Nerve Tissue Engineering.
Aydemir Sezer, U.; Ozturk Yavuz, K.; Ors, G.; Bay, S.; Aru, B.; Sogut, O.; Akgul Caglar, T.; Bozkurt, M. R.; Cagavi, E.; Yanikkaya Demirel, G.; Sezer, S.; Karaca, H. Zero-Valent Iron Nanoparticles Containing Nanofiber Scaffolds for Nerve Tissue Engineering. J Tissue Eng Regen Med 2020, 14 (12), 1815–1826. https://doi.org/10.1002/term.3137.
Effects of Early and Delayed Laser Application on Nerve Regeneration.
Akgul T.; Gulsoy M.; Gulcur, H. Effects of Early and Delayed Laser Application on Nerve Regeneration. Lasers in medical science 2014, 29 (1). https://doi.org/10.1007/s10103-013-1355-9.

