Özgecan Şavluğ İpek
[email protected]Özgecan Şavluğ İpek graduated from Yildiz Technical University Department of Chemistry in 2014 with second degree. Then, she received her MSc degree in Organic Chemisry from Yıldız Techical University in 2016 and meanwhile she carried out her experimental studies in Organic Materials Chemistry Research Group at Istanbul Technical University. After completion of her graduate studies, she started her PhD at Yıldız Technical University Organic Chemistry and joined Istanbul Medipol University-SABITA-Güzel Research Group. She has been working at SABITA (Health Sciences and Technologies Research Institute) since 2017.
Her main research interests are oganic chemistry, synthesis of small molecules, total synthesis, drug discovery and development.
Selected Publications;
Synthesis of Novel Methyl Jasmonate Derivatives and Evaluation of their Biological Activity in Various Cancer Cell Lines
Sucu, Bilgesu O; Savlug I., Ozgecan; Ozdatlı K., Sukran; Yazıcı; Busra E; Karakas, Nihal, Guzel, Mustafa. “Synthesis of novel methyl jasmonate derivatives and evaluation of their biological activity in various cancer cell lines” Bioorganic Chemistry, 2019, 91, 10346. https://doi.org/10.1016/j.bioorg.2019.103146.
Design and Synthesis of Novel Cylopentapyrazoles Bearing 1,2,3-Thiadiazole Moiety as Potent Antifungal Agents
Giray, Betül; Karadağ, Ayşe E; Savlug I., Ozgecan; Pekel, Hanife; Guzel, Mustafa; Kucuk, Hatice B. “Design and synthesis of novel cylopentapyrazoles bearing 1,2,3-thiadiazole moiety as potent antifungal agents” Bioorganic Chemistry, 2020, 95, 103509 https://doi.org/10.1016/j.bioorg.2019.103509.
Synthesis, Characterization and Sensing Properties of Donor-Acceptor Systems Based Dithieno[3,2-b;2′,3′-d]Thiophene and Boron
Savlug I., Ozgecan; Topal, Sebahat; Ozturk, Turan.“Synthesis, characterization and sensing properties of donor-acceptor systems based Dithieno[3,2-b;2′,3′-d]thiophene and boron”Dyes and Pigments, 2021, 192, 109458. https://doi.org/10.1016/j.dyepig.2021.109458.
Electrochromic-Hybrid Energy Storage Material Consisting of Triphenylamine and Dithienothiophene
Topal, Sebahat; Savlug I. Ozgecan; Sezer, Esma; Ozturk, Turan. “Electrochromic-Hybrid energy storage material consisting of triphenylamine and dithienothiophene” Chemical Engineering Journal, 2022, 434, 133868. https://doi.org/10.1016/j.cej.2021.133868.
Design and Synthesis of Novel Caffeic Acid Phenethyl Ester (CAPE) Derivatives and their Biological Activity Studies in Glioblastoma Multiforme (GBM) Cancer Cell Lines
Sucu, Bilgesu O; Koc, Elif B.; Savlug I., Ozgecan; Mirat, Afranur; Almas, Furkan; Guzel, Melike A.; Dogan, Berna; Uludağ, Damla; Karakas, Nihal; Durdagı, Serdar; Guzel, Mustafa. “Design and synthesis of novel caffeic acid phenethyl ester (CAPE) derivatives and their biological activity studies in glioblastoma multiforme (GBM) cancer cell lines” Journal of Molecular Graphics and Modelling, 2022, 113, 108160. https://doi.org/10.1016/j.jmgm.2022.108160.
Discovery of a Small Molecule that Selectively Destabilizes Cryptochrome 1 and Enhances Life Span in p53 Knockout Mice
Gul, Seref; Akyel, Yasemin K.; Gul, Zeynep M.; Isin, Safak; Ozcan, Onur; Korkmaz, Tuba; Selvi, Saba; Danis, Ibrahim; Savlug I., Ozgecan; Aygenli, Fatih; Taskin, Ali C.; Aytul A., Büşra; Ozlu, Nurhan; Ozturk, Nuri; Ozturk, Narin; Ozer U., Durişehvar; Guzel, Mustafa; Turkay, Metin; Okyar, Alper; Kavaklı I.Halil. “Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice”. Nature Commun. 2022, 13, 6742. https://doi.org/10.1038/s41467-022-34582-1.
Potential of Novel Methyl Jasmonate Analogs as Anticancer Agents to Metabolically Target HK-2 Activity in Glioblastoma Cells
Uludağ, Damla; Bay, Sadık; Sucu, Bilgesu O., Savlug I., Ozgecan; Mohr, Thomas; Guzel, Mustafa; Karakas, Nihal. “Potential of Novel Methyl Jasmonate Analogs as Anticancer Agents to Metabolically Target HK-2 Activity in Glioblastoma Cells” Front. Pharmacol. 2022, 13, 828400. https://doi.org/10.3389/fphar.2022.828400.