Assoc. Prof. S. Sibel Erdem
Sibel Erdem received a B.S. degree in Chemical Education from Marmara University. She then earned her Ph.D. degree in Bioorganic/Biochemistry at the Louisiana State University where her research focused on the development of new synthetic method for the synthesis of near-IR fluorophores and fluorescence based assays for diverse applications from single gene mutation detection in DNA to monitoring inhibitor/activator action on therapeutic targets. After completion of her graduate studies she has accepted a postdoctoral fellowship position at the Harvard Medical School (HMS) and Massachusetts General Hospital (MGH) in 2009. During her postdoctoral studies she worked in two different centers at the HMS. In the first phase of her postdoctoral studies, Dr. Erdem joined Dr. Jason McCarthy’s laboratory in the Center for Systems Biology at HMS and MGH. She has become immersed in preparation of drug delivery vehicles decorated with light-activated molecules for detection and treatment of cardiovascular diseases using photodynamic therapy. After completion of her studies, she joined to Dr. Tayyaba Hasan’s laboratory in the department of Wellman Center for Photomedicine at HMS and MGH, where she worked on the development of fluorescent probes for point-of–care system to determine beta lactamase resistance and antibiotic susceptibility of the pathogens as well as preparation of activatable immunoconjugates for photodynamic therapy based selective treatment and monitoring of disseminated cancer micrometastases.Dr. Erdem is currently holding a faculty position in the Department of Medical Biochemistry in the International School of Medicine. Her main research interests are: targeted drugs and nanoparticle based drug delivery systems for photodynamic therapy of cancer, biomarker based fluorescent probes for detection and treatment of cancer and other diseases, Light activated molecules for medical applications
Selected Publications;
Development of light and pH-dual responsive self-quenching theranostic SPION to make EGFR overexpressing micro tumors glow and destroy
Verimli N, Goralı Sİ, Abisoglu B, Altan CL, Sucu BO, Karatas E, Tulek A, Bayraktaroglu C, Beker MC, Erdem SS. Development of light and pH-dual responsive self-quenching theranostic SPION to make EGFR overexpressing micro tumors glow and destroy. J Photochem Photobiol B. 2023 Oct 10;248:112797. doi: 10.1016/j.jphotobiol.2023.112797. Epub ahead of print. PMID: 37862898.
Rapid, Low-cost Fluorescent Assay of Beta-Lactamase Derived Antibiotic Resistance and Related Antibiotic Susceptibility
Erdem, Sibel S.; Khan, Shazia, Palanasami, Akilan and Hasan, Tayyaba. “Rapid, Low-cost Fluorescent Assay of Beta-Lactamase Derived Antibiotic Resistance and Related Antibiotic Susceptibility" Journal of Biomedical Optics, 2014, 19, 10, 105007.
Photodynamic Therapy: One Step Ahead With Self-Assembled Nanoparticles
Avci, Pinar; Erdem, Sibel S.; Hamblin, Michael R. “Photodynamic Therapy: One Step Ahead with Self-Assembled Nanoparticles” Journal of Biomedical Nanotechnology, 2014, 10, 1–16.
Selective Treatment and Monitoring of Disseminated Cancer Micrometastases in Vivo Using Dual-Function Activatable Immunoconjugates
Spring, Q. Bryan; Abu-Yousif, O. Adnan.; Palanisami, Akilan.; Zheng, Xiang.; Anbil, Sriram; Sears, R. Bryan; Mensah, B. Lawrence; Goldschmidt, Ruth; Erdem, Sibel S;Oliva, Esther; Hasan, Tayyaba. “Selective treatment and monitoring of disseminated cancer micrometastases in vivo using dual-function activatable immunoconjugates” Proceeding of National Academia of Science U.S.A ., 2014, 11, 10, E933-E942.
Bis[2,3,4-trimethyl-5-[(3,4,5-trimethyl-2H-pyrrol-2-yl-idene-κ N)meth-yl]-1H-pyrrolato-κ N]copper(II)
Erdem, Sibel S; Fronczek, Frank R.; Watkins, Steven F. “Bis[2,3,4-trimethyl-5-[(3,4,5-trimethyl-2H-pyrrol-2-yl-idene-κ N)meth-yl]-1H-pyrrolato-κ N]copper(II)” Acta Crystallogr. Sect E Struct. Rep. Online. 2012, 68 (11), 1335-1336.
Multifunctional Nanoagent for Thrombus-Targeted Fibrinolytic Therapy
McCarthy, Jason R.; Sazonova, Irina Y.; Erdem, Sibel S.; Hara, Tetsuya.; Thompson, Brian D.; Patel, Purvish.; Botnaru, Ion.; Lin, Charles P.; Reed, Guy L.; Weissleder, Ralph and Jaffer, Farouc A. “Multifunctional Nanoagent for Thrombus-targeted Fibrinolytic Therapy” Nanomedicine , 2012,7, 1017-1028.
Targeted Nanoagents for the Detection of Cancers
McCarthy, Jason R.; Bhaumik, Jayeeta; Karver, Mark R.; Erdem, S. Sibel.; Bardon, Kevin.; and Weissleder, Ralph. “Targeted Nanoagents for the Detection of Cancers” Molecular Oncology, 2010, 4, 511-528.
Monoamine Functionalized Phthalocyanines: Microwave-Assisted Solid-Phase Synthesis and Bioconjugation Strategies
Erdem, Sibel S.; Nesterova, Irina V.; Soper, Steven A. and Hammer, Robert P. “Monoamine Functionalized Phthalocyanines: Microwave-Assisted Solid-Phase Synthesis and Bioconjugation Strategies” The Journal of Organic Chemistry , 2009, 74, 9280-9286.
Phthalocyanine Dimerization-Based Molecular Beacons Using Near-IR Fluorescence
Nesterova, Irina V.; Erdem, Sibel S.; Pakhomov, Serhii.; Hammer, Robert P. and Soper, Steven A. “Phthalocyanine Dimerization-Based Molecular Beacons Using Near-IR Fluorescence” The Journal of American Chemical Society , 2009, 131, 2432-2433.
Solid- Phase Synthesis of Asymmetrically Substituted “AB3 ” Type Phthalocyanines
Erdem, Sibel S.; Nesterova, Irina V.; Soper, Steven A. and Hammer, Robert P. “Solid- Phase Synthesis of Asymmetrically Substituted “AB3 ” Type Phthalocyanines”, The Journal of Organic Chemistry , 2008, 73, 5003-5007.
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