İlyas Özçiçek
[email protected]Ilyas Ozcicek completed his undergraduate in Faculty of Art and Science, Department of Biology, Kırıkkale University (Turkey) in 2009 and gained his Ph.D. degree in the Nanotechnology and Nanomedicine (Integrated MSc. and PhD) program, Hacettepe University (Turkey) in 2016. His PhD thesis was supported by TUBİTAK with a doctorate scholarship program for priority areas. Dr. Ilyas Ozcicek worked as a research assistant at Istanbul Medipol University, School of Medicine, Department of Medical Biology between 2010 and 2018. He currently works as an associate professor in the same department. After his doctorate, he carried out and successfully completed two TUBİTAK (3001 and 1001 programs) projects.
My expertise is based on the following:
• Biomedical applications of gold nanomaterials (toxicology, biodistribution, bioimaging, tissue/organ engineering, cancer therapy, drug delivery, gene silencing, antibacterial applications, antioxidant applications, etc.).
• Development of biocompatible, conductive, biologically modified, micro/nano-topographic tissue scaffold biomaterials using natural and synthetic polymers for neural tissue engineering applications.
• Neural stem cell studies.
• Obtaining primary neural cells from animals. Animal models for various nerve injuries.
• Use of lithographic techniques to obtain micro- and nano-patterning on biomaterial surfaces.
• Advanced microscopy studies.
Selected Publications;
The Effects of Various Surface Coatings of Gold Nanorods on Toxicity, Neuronal Localization, Microstructural Alterations, and In vitro/In vivo Biodistribution
I. Ozcicek*, N. Aysit, C. Cakici, N.U. Ayturk, A. Aydeger, U.C. Erim, The Effects of Various Surface Coatings of Gold Nanorods on Toxicity, Neuronal Localization, Microstructural Alterations, and In vitro/In vivo Biodistribution, Advanced Materials Interfaces 9(3) (2022) 2101369.
The effects of surface functionality and size of gold nanoparticles on neuronal toxicity, apoptosis, ROS production and cellular/suborgan biodistribution
I. Ozcicek*, N. Aysit, C. Cakici, A. Aydeger, The effects of surface functionality and size of gold nanoparticles on neuronal toxicity, apoptosis, ROS production and cellular/suborgan biodistribution, Mater Sci Eng C Mater Biol Appl 128 (2021) 112308.
Quercetin/Polyethyleneimine Modified Gold Nanoconjugates Inhibit Apoptosis and ROS Production Induced by Hydrogen Peroxide in DRG Sensory Neurons
I. Ozcicek*, G. Baydas, U.C. Erim, U.V. Ustundag, Quercetin/Polyethyleneimine Modified Gold Nanoconjugates Inhibit Apoptosis and ROS Production Induced by Hydrogen Peroxide in DRG Sensory Neurons, Journal of Pharmaceutical Sciences 113(10) (2024) 3088-3099.
Functionalized gold nanoparticles manifested as potent carriers for nucleolar targeting
R. Shahbazi & I. Ozcicek (contributed equally), G. Ozturk, K. Ulubayram*, Functionalized gold nanoparticles manifested as potent carriers for nucleolar targeting, Nanotechnology 28(2) (2017) 025103.
Development of BDNF/NGF/IKVAV Peptide Modified and Gold Nanoparticle Conductive PCL/PLGA Nerve Guidance Conduit for Regeneration of the Rat Spinal Cord Injury
I. Ozcicek*, N. Aysit, Z. Balcikanli, N.U. Ayturk, A. Aydeger, G. Baydas, M.S. Aydin, E. Altintas, U.C. Erim, Development of BDNF/NGF/IKVAV Peptide Modified and Gold Nanoparticle Conductive PCL/PLGA Nerve Guidance Conduit for Regeneration of the Rat Spinal Cord Injury, Macromol Biosci 24(5) (2024) e2300453.
A critical review of in vitro and in vivo biomedical applications of gold nanoparticles: From toxicology to cancer therapy
I. Ozcicek*, A critical review of in vitro and in vivo biomedical applications of gold nanoparticles: From toxicology to cancer therapy, Biomed Pharmacother 190 (2025) 118410.
Design of IKVAV peptide/gold nanoparticle decorated, micro/nano-channeled PCL/PLGA film scaffolds for neuronal differentiation and neurite outgrowth
A. Aydeger, N. Aysit, G. Baydas, C. Cakici, U.C. Erim, M.D. Arpa, I. Ozcicek*, Design of IKVAV peptide/gold nanoparticle decorated, micro/nano-channeled PCL/PLGA film scaffolds for neuronal differentiation and neurite outgrowth, Biomater Adv 152 (2023) 213472.