SABITALKS / Directional tract density patterns of brain white matter for understanding hereditary neurogical disorders
Dr. Ali Demir is going to be at SABITALKS on December 5, 2025 at 14:00, and will give a presentation titled “Directional tract density patterns of brain white matter for understanding hereditary neurogical disorders.” The event will take place in person.
Location: Istanbul Medipol University North Campus / A Block, 3rd Floor – Senate Room.
https://goo.gl/maps/JDDjygVtFLWiPiMJA
*Participants from outside SABITA must fill in the participation form.
Directional tract density patterns of brain white matter for understanding hereditary neurogical disorders
It has been shown that altered white matter structure is an important indicator of neurological and hereditary disorders. However, white matter connectivity is evaluated mostly by locating parcellated cortical (source/target) regions as constraints of the tractography, where the cortical regions had the greatest tracking uncertainty. We have addressed some of these issues in our prior publications, and provided a quantification for interhemispheric connectivity using directional tract density pattern (dTDP) approach and showed changes in corpus callosum in the progression of Huntington’s Disease, a hereditary and neurological disorder. In this talk, I will briefly introduce our contributions and advancements with possible future studies.
Dr. Demir received his B.S. degree with a double major in Computer Engineering and Biomedical Engineering from Yeditepe University (2008, Istanbul, Türkiye). Then, he completed a M.Sc. program of Electronics Engineering at Sabancı University (2010, His PhD study (awarded in 2020) was about macroscopic characterization approaches of the brain white matter integrity using diffusion MRI and tractography. He was a research fellow (2021-2025) in the Department of Neurology at Massachusetts General Hospital (Boston, USA), where he worked on novel methods for detection of early white matter changes in neurological disorders, such as Huntington’s disease and Alzheimer’s disease in Down syndrome. He also served as a director of Computer Programming program (2015 to 2021) of Istanbul Medipol University, Vocational School.