Prof. Young-Tae Chang from Pohang University of Science and Technology (POSTECH) is going to be at SABITALKS on March 7, 2025 at 10:00. The event will take place in person. You can attend the event in person in C Block, 1st Floor, Senate Room.
Location: Istanbul Medipol University Kavacık North Campus: https://goo.gl/maps/JDDjygVtFLWiPiMJA
*Participants from outside SABITA must fill in the participation form.
Aging is a complex biological process characterized by progressive changes at the cellular level, necessitating advanced tools for visualizing and distinguishing different cell types and states. We have developed a comprehensive suite of fluorescent probes designed for real-time cell visualization and discrimination, with a particular emphasis on aging research. This multi-dimensional probe system encompasses various cellular characteristics, including Protein Oriented Live-cell Distinction (POLD), Carbohydrate (COLD), Gating (GOLD), Lipid (LOLD), and Metabolism (MOLD). Our approach enables detailed characterization of diverse cell types, such as stem cells, immune cells, and senescent cells, while MOLD provides valuable insights into metabolic signatures across different cell stages. This novel methodology has successfully identified distinct metabolic profiles in young versus aged stem cells, tracked age-related changes in immune cell surface markers, and detected senescence-associated lipid composition alterations.
Young-Tae Chang is a South Korean chemist. He is a professor of chemistry at Pohang University of Science and Technology (POSTECH) and Associate Director under Kim Kimoon at the Center for Self-assembly and Complexity at the Institute for Basic Science located on the POSTECH campus. Young-Tae Chang was born in Busan, South Korea in 1968. He obtained a Bachelor of Science degree in chemistry from POSTECH, working on the divergent synthesis of all regioisomers of myo-inositol phosphates, under guide of Prof. Sung-Kee Chung. Doctoral requirements at POSTECH require a student study at least three years, but Young-Tae finished in two, requiring his advisor to appeal for a revision of the rules which allowed him to receive his doctorate in February 1997. He then engaged in postdoctoral research in the laboratory of Prof. Peter G. Schultz at University of California, Berkeley and Scripps Research in 2000. He was appointed assistant professor at New York University (NYU) and promoted to associated professor in 2005. In September 2007, he moved to the National University of Singapore and the Singapore Bioimaging Consortium at Biopolis. From 2017, he is a Full Professor in the Department of Chemistry, POSTECH and head of the Laboratory of Bioimaging Probe Development at SBIC. He pioneered diversity-oriented fluorescence library approach (DOFLA), and developed embryonic stem cell probe CDy1, neuronal stem cell probe CDr3, and neron specific probe, NeuO. He also developed a method for background-free live cell imaging with tamed fluorescent probe. He is an editorial board member of MedChemComm and RSC Advances, Royal Society of Chemistry, and American Journal of Nuclear Medicine and Molecular Imaging. He has published more than 300 scientific papers and 3 books resulting in more than 22,000 citations. Additionally, he has filed more than 50 patents.