Article / Clinical Neurophysiology
Abnormal electroencephalographic rhythms from quiet wakefulness to light sleep in Alzheimer’s disease patients with mild cognitive impairment
Enrico Michele Salamone, Matteo Carpi, Giuseppe Noce, Claudio Del Percio, Susanna Lopez, Roberta Lizio, Dharmendra Jakhar, Ali Eldellaa, Veronica Henao Isaza, Burcu Bölükbaş, Andrea Soricelli, Marco Salvatore, Bahar Güntekin, Görsev Yener, Federico Massa, Dario Arnaldi, Francesco Famà, Matteo Pardini, Raffaele Ferri, Michele Salemi, Claudio Babiloni
Abstract
Objectives
Alzheimer’s disease patients with mild cognitive impairment (ADMCI) show abnormal resting-state eyes-closed electroencephalographic (rsEEG) alpha rhythms (8–12 Hz) and may suffer from daytime sleepiness. Our exploratory study tested the hypothesis that they may present characteristic EEG rhythms from quiet wakefulness to light sleep during diurnal recordings.
Methods
Results
ADMCI (t-ADMCI, N = 18) over Nold (t-Nold, N = 11) participants were characterized by greater frontal EEG delta source activities and a lesser reduction (reactivity) in the posterior alpha source activities from quiet wakefulness to ripples. Notably, EEG delta source activities during quiet wakefulness were also greater in the ADMCI group transitioning to light sleep as compared to patients without said vigilance reduction.
Conclusions
Significance
Our study showed a derangement of EEG rhythms during the transition to sleep possibly specific to AD.