SABITALKS / Gene Therapy for Ion Channels
Dr. Enes Akyüz from University of Wisconsin-Madison is going to be at SABITALKS on September 18, 2024 at 14:00. The event will take place in person. You can attend the event in person in Lecture Hall C-412.
Location: Istanbul Medipol University Kavacık North Campus: https://goo.gl/maps/JDDjygVtFLWiPiMJA
*Participants from outside SABITA must fill in the participation form.
Gene Therapy for Ion Channels
It will be about KCNJ13 nonsense mutation leading to channelopathy on Kir7.1 ion channel. This dysfunction of the channel lead LCA and we do gene therapy via enginereed tRNA.
My key focus of research is channelopathy, defects in inwardly rectifying potassium channel 7.1 (Kir7.1) proteins, leading to congenital blindness. I am working on the mutations in retinal pigment epithelium Kir7.1 channels cause blindness such as Leber congenital amaurosis (LCA). I am currently doing several in-vitro (HEK293 and patient-derived induced pluripotent stem cells iPSC-RPE) and in-vivo (genetically engineered mouse) models to study cell, tissue, organ, and animal physiology. I am using techniques like patch-clamp, biological imaging, molecular techniques to repair Kir7.1 channel defects in the hope to treat blindness.