SABITALKS / Roles of Sphingolipid Signaling in Metabolic Stress

Besim Ogretmen is director at the “Lipidomics Shared Resource, Hollings Cancer Center, Medical University of South Carolina.” Also he is a leader in the Developmental Cancer Therapeutics Program, Hollings Cancer Center, Medical University of South Carolina.”

Dr. Ogretmen’s research is focused on deciphering the regulation and function of bioactive sphingolipids, specifically ceramide and sphingosine-1-phosphate, in cancer development/progression and therapy. Specifically, he investigates the roles and mechanisms of action of ceramide, an emerging tumor suppressor lipid which induces antiproliferative and apoptotic responses. The long-term goal of these studies is to develop mechanism-based therapeutic strategies against human cancers.