Assist. Prof. Şerife Yerlikaya
[email protected]She completed her undergraduate in Faculty of Art and Science, department of Biology, Abant Izzet Baysal University (Turkey) in 2013 and gained her master’s degree in Biochemistry and PhD degree in Genetics and Bioengineering in 2019. Immediately afterwards, she was appointed as Assistant Professor in Istanbul Medipol University in the institute for health science and technologies. During her research in the lab, she mainly focused on to the effects of combinations on apoptosis and several intracellular signal transduction pathways related to ion channels in breast cancer cells. She used bortezomib (a proteasome inhibitor) and BAPTA (a cell permeant Ca2+ chelator) on 4T1 breast cancer cells. At the same time, she became increasingly aware of the ‘neuroscience’ approach and the burgeoning field of ion channels and cancer. In November 2022, she attended to Dr. William Brackenbury’s Lab at University of York as a postdoctoral researcher with a project funded by Turkish Scientific Research Council of Turkey (TUBITAK-2219). She continues to work on voltage gated sodium channels (VGSCs) in metastatic breast cancer cells targetting to increase the effectiveness of chemotherapy and to reduce its neuropathic impact.
Selected Publications;
Voltage-Gated Sodium Channels, Sodium Transport and Progression of Solid Tumours
Jodie R. Malcolm, Nattanan Sajjaboontawee, Serife Yerlikaya, Charlotte Plunkett-Jones, Peter J. Boxall, William J. Brackenbury. Voltage-gated sodium channels, sodium transport and progression of solid tumours.Current Topics in Membranes.Academic Press. 2023. https://doi.org/10.1016/bs.ctm.2023.09.005.
Antiproliferative Properties and Structural Analysis of Newly Synthesized Schiff Bases Bearing Pyrazole Derivatives and Molecular Docking Studies.
Şener, N., Özkınalı, S., Celik Altunoglu Y., Yerlikaya, S., Gökçe, H., Zurnacı, M., Gür M., Baloglu, M.C., Şener, İ. Antiproliferative Properties and Structural Analysis of Newly Synthesized Schiff Bases Bearing Pyrazole Derivatives and Molecular Docking Studies. Journal of Molecular Structure 1241(2):130520
Exploring of Coronilla Varia L. Extracts as a Source of High-Value Natural Agents: Chemical Profiles and Biological Connections.
Yerlikaya, S., Baloglu, M.C., Celik Altunoglu Y., Diuzheva, A., Jekő, J., Cziáky, Z., Zengin, G. Exploring of Coronilla varia L. extracts as a source of high-value natural agents: Chemical profiles and biological connections. South African Journal of Botany. 000 (2021)1-11.
A Brief Overview to TNF-a Inhibitors Therapy on Covid-19: Functions Inside Cell Cascades.
Yerlikaya, S*., A Brief Overview to TNF-a Inhibitors Therapy on Covid-19: Functions Inside Cell Cascades. Lupine Online Journal of Pharmacology and Clinical Research 2644-1373 (2020).
Antiproliferative-Antimicrobial Properties and Structural Analysis of Newly Synthesized Schiff Bases Derived from Some 1, 3, 4-Thiadiazole Compounds
Gür, M., Yerlikaya, S., Şener, N., Özkınalı, S., Baloglu, M. C., Gökçe, H.,Celik Altunoglu Y., Demir S. & Şener, İ. Antiproliferative-Antimicrobial Properties and Structural Analysis of Newly Synthesized Schiff Bases Derived from Some 1, 3, 4-Thiadiazole Compounds. Journal of Molecular Structure, 128570 (2020).
Exploring the Nutraceutical Potential of Dried Pepper Capsicum Annuum L. on Market from Altino in Abruzzo Region.
Valle, A,D, Dimmito, M.P, Zengin, G., Pieretti, S., Mollica, A., Locatelli, M., Cichelli, A., Novellino, E., Ak, G.,Yerlikaya, S., Baloglu, M.C., Altunoglu, Y.C., Stefanucci A. Exploring the Nutraceutical Potential of Dried Pepper Capsicum Annuum L. on Market from Altino in Abruzzo Region. Antioxidants, 9(5), 400 (2020).
Utilisation of Rhododendron Luteum Sweet Bioactive Compounds as Valuable Sourceof Enzymes Inhibitors, Antioxidant, and Anticancer Agents.
Mahomoodally, F.M., Sieniawska, E., Sinan, K.I., Picot-Allain, M.C.N., Yerlikaya, S., Baloglu, M.C., Altunoglu, Y.C., Senkardes, I., Rengasamy, K., Zengin, G., Utilisation of Rhododendron Luteum Sweet Bioactive Compounds as Valuable Sourceof Enzymes Inhibitors, Antioxidant, and Anticancer agents. Food and Chemical Toxicology (2020).
Investigation of Chemical Profile, Biological Properties of Lotus Corniculatus L. Eextracts and Their Apoptotic-Autophagic Effects on Breast Cancer Cells.
Yerlikaya, S., Baloglu, M.C., Diuzheva, A., Jekő, J., Cziáky, Z., Zengin, G. Investigation of chemical profile, biological properties of Lotus corniculatus L. extracts and Their apoptotic-autophagic effects on breast cancer cells, Journal of Pharmaceutical and Biomedical Analysis (2019).
Pharmacological and Polyphenolic Profiles of Phyllanthus Phillyreifolius var. Commersonii Müll. Arg: An Unexplored Endemic Species from Mauritius.
Mahomoodally, F.M., Yerlikaya, S., Llorent-Martínez, E.J., Uğurlu, A., Baloglu, M.C., Altunoglu, Y.C., Mollica, A., Kurty, K.D., Aumeeruddy M.Z., Puchooa, D., Zengin, G., Pharmacological and polyphenolic profiles of Phyllanthus phillyreifolius var. Commersonii Müll. Arg: An unexplored endemic species from Mauritius, Food Research International (2018).
Investigations into the Therapeutic Potential of Asphodeline Liburnica Roots: in Vitro and in Silico Biochemical and Toxicological Perspectives.
Locatelli, M*., Yerlikaya, S*., Baloglu, M.C., Zengin, G., Altunoglu, Y.C.,Cacciagrano, F., Campestre, C., Mahomoodally, F.M., Mollica, A. Investigations into the therapeutic potential of Asphodeline liburnica roots: in vitro and in silico biochemical and toxicological perspectives, Food and Chemical Toxicology (2018). (*: contributed equally).
Anticancer, Antimicrobial, and DNA Protection Analysis of Novel 2,4- Dihydroxyquinoline Dyes.
Şener, N., Mohammed H.,J.,A., Yerlikaya S., Altunoglu, Y.C., Gür, M., Baloglu, M.C., Şener, İ. Anticancer, antimicrobial, and DNA protection analysis of novel 2,4- dihydroxyquinoline dyes, Dyes and Pigments (2018).
A Multidirectional Perspective for Novel Functional Products: In vitro Pharmacological Activities and In silico Studies on Ononis Natrix subsp.hispanica.
Yerlikaya, S*., Zengin, G., Mollica, A., Baloglu, M.C., Altunoglu, Y.C., Aktumsek, A., A Multidirectional Perspective for Novel Functional Products: In vitro Pharmacological Activities and In silico Studies on Ononis Natrix subsp.hispanica, Frontiers in Pharmacology (2017). (*: corresponding author).
A New Combination Treatment Involving GRP78 Inhibitor BAPTA-AM and Proteasome Inhibitor Bortezomib for Breast Cancer Cells.
Yerlikaya, A., Erdoğan, E., Okur, E., Yerlikaya, S., Savran, B., A New Combination Treatment Involving GRP78 Inhibitor BAPTA-AM and Proteasome Inhibitor Bortezomib for Breast Cancer Cells, Oncology Letters. (2016).
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