The R3FINE 2026 International Conference will be held on June 11–14, 2026, in Istanbul, organized by Istanbul Medipol University SABITA. The conference focuses on the 3R principles (Replace, Reduce, Refine), New Approach Methodologies (NAMs), and innovative animal-free research strategies. R3FINE 2026 aims to bring together international researchers, experts, and early-career scientists through scientific sessions, panel discussions, and hands-on workshops. (https://r3fine.org/)