Toghrul Almammadov
[email protected]Dr. Toghrul Almammadov participated in many national and international chemistry competitions during high school stages, since of his deep interest in natural sciences. As a result, he received bronze medal in International Chemistry Olympiads (IChO) both in 2008, and 2009, held in Hungary, and UK, respectively. Later, he completed his BSc in Middle East Technical University in Chemistry with honors, and moved to Koc University for his PhD studies. He explored and synthesized small organic molecules in the diagnosis and treatment of deep tumors. To address this, his thesis was focused on the implementation of red-shifted photosensitizers as effective Photodynamic Therapy (PDT) agents in the selective ablation of cancer cells. After specializing in Organic Chemistry and Chemical Biology fields, he moved to the University of Zurich, for a postdoctoral period for exploring reactivity and magnetic properties of nanographenes for further expand his knowledge in aromatic chemistry. Currently he is working on nanoparticle assembled photosensitizers for targeted cancer therapy, and small organic molecule synthesis for cancer diagnostics. Dr. Almammadov’s research interests include rational design of molecular sensors for improved cancer selectivity, organelle targeting strategies in visualization and treatment of cancer cells, expression of cancer biomarkers and their inhibition mechanisms.
In 2023, Dr. Toghrul Almammadov and co-workers could implement red-shifted fluorophore for highly selective detection of melanoma cells. Moreover, Dr. Toghrul Almammadov also collaborates with other groups for other interfaces of biological sciences.
Furthermore, Dr. Toghrul Almammadov delivers lectures for high school olympiad students on behalf of TUBITAK camps.
Selected Publications
Sulfide-Capped InP/ZnS Quantum Dot Nanoassemblies for a Photoactive Antibacterial Surface
Khan, S.; Surme, S. ; Eren, Guncem O.; Almammadov, T.; Pehlivan, C.; Kaya, L.; Hassnain, M.; Onal, A.; Balamur, R.; Sahin, A.; Kolemen, S.; Vanalakar, S. A.; Alkan, F.; Kavakli, I.; Nizamoglu, S. Sulfide-Capped InP/ZnS Quantum Dot Nanoassemblies for a Photoactive Antibacterial Surface. ACS Appl. Nano Mater. 2024, 7, 5922–5932.
Antibacterial Type-II InP/ZnO Quantum Dots via Multimodal Reactive Oxygen Species
Khan, S. U.; Eren, G. O.; Atac, N.; Onal, A.; Qureshi, M. H.; Cooper, F. K.; Almammadov, T.; Kolemen, S.; Sahin, M.; Can, F.; Nizamoglu, S. Antibacterial Type-II InP/ZnO Quantum Dots via Multimodal Reactive Oxygen Species. Chem. Eng. J. 2024, 480, 148140.
A Hydrogen Sulfide and Tyrosinase Responsive Dual-locked Fluorophore for Selective Imaging of Melanoma Cells
Almammadov, T.; Dirak, M.; Saymaz, A.; Acari, A..; Kolemen, S. A Hydrogen Sulfide and Tyrosinase Responsive Dual-locked Fluorophore for Selective Imaging of Melanoma Cells. Chem. Commun. 2023, 59, 9972-9975.
Real-time visualization of butyrylcholinesterase activity using a highly selective and sensitive chemiluminescent probe
Acari, A.; Almammadov, T.; Dirak, M.; Gulsoy, G.; Kolemen, S. Real-time visualization of butyrylcholinesterase activity using a highly selective and sensitive chemiluminescent probe. J. Mater Chem. B 2023, 11, 6881-6888.
Directing Chemiluminescent Dioxetanes to Mitochondria: A Cationic Luminophore Enables in Vitro and in Vivo Detection of Cancer Cells Upon Enzymatic Activation
Gunduz, H.; Acari, A.; Cetin, S.; Almammadov, T.; Pinarbasi-Degirmenci, N.; Dirak, M.; Cingoz, A.; Kilic, E.; Bagci-Onder, T.; Kolemen, S. Directing Chemiluminescent Dioxetanes to Mitochondria: A Cationic Luminophore Enables in Vitro and in Vivo Detection of Cancer Cells Upon Enzymatic Activation. Sens. Actuators B Chem. 2023, 133574.
Selective monitoring and treatment of neuroblastoma cells with hydrogen sulfide activatable phototheranostic agen
Dirak, M., Kepil, D., Almammadov, T.; Elmazoglu, Z.; Cetin, S.; Ozogul, N.; Gunbas, G.; Kolemen, S. Selective monitoring and treatment of neuroblastoma cells with hydrogen sulfide activatable phototheranostic agent. Dyes Pigm. 2023, 210, 111011.
Selective detection of carboxylesterase 2 activity in cancer cells using an activity-based chemiluminescent probe
Ozsan, C.; Kailass, K.; Digby, E. M.; Almammadov, T.; Beharry, A.; Kolemen, S. Selective detection of carboxylesterase 2 activity in cancer cells using an activity-based chemiluminescent probe. Chem. Commun. 2022, 58, 10929-10932.
Locked and loaded: β-galactosidase activated photodynamic therapy agent enables selective imaging and targeted treatment of glioblastoma multiforme cancer cells
Almammadov, T.; Elmazoglu Z.; Atakan, G.; Kepil, D.; Aykent, G.; Kolemen, S; Gunbas, G. Locked and loaded: β-galactosidase activated photodynamic therapy agent enables selective imaging and targeted treatment of glioblastoma multiforme cancer cells. ACS Appl. Bio Mater. 2022, 5, 4284–4293.
Superior Photodynamic Therapy of Colon Cancer Cells by Selenophene-BODIPY-Loaded Superparamagnetic Iron Oxide Nanoparticles
Sertcelik Ozvural, K. N; Karaman, O.; Almammadov, T.; Gunbas, G.; Kolemen, S. Yagci Acar, H.; Bilici, K. “Superior Photodynamic Therapy of Colon Cancer Cells by Selenophene-BODIPY-loaded Superparamagnetic Iron Oxide Nanoparticles. ChemPhotoChem 2022, 6, e20220010
Activity-Based Photosensitizers with Optimized Triplet State Characteristics Towards Cancer Cell Selective and Image Guided Photodynamic Therapy.
Kilic, E; Elmazoglu Z.; Almammadov, T.; Kepil, D.; Etienne, T.; Marion A.; Gunbas, G.; Kolemen, S. Activity-Based Photosensitizers with Optimized Triplet State Characteristics Towards Cancer Cell Selective and Image Guided Photodynamic Therapy. ACS Appl. Bio Mater. 2022, 5, 2754–2767.
A Leucine Aminopeptidase Activatable Photosensitizer for Cancer Cell Selective Photodynamic Therapy Action
Arslan, B.; Bilici, K.; Durmaz, G.; Almammadov, T.; Khan, M.; Sennaroglu, A.; Yagci Acar, H.; Kolemen, S. A Leucine Aminopeptidase Activatable Photosensitizer for Cancer Cell Selective Photodynamic Therapy Action. Dyes Pigm., 2021, 195,
A Hydrogen Peroxide Responsive Resorufin-Based Phototheranostic Agent for Selective Treatment of Cancer Cells
Almammadov, T.; Kolemen, S. A Hydrogen Peroxide Responsive Resorufin-Based Phototheranostic Agent for Selective Treatment of Cancer Cells. Dyes Pigm., 2021, 193, 109499.
Resorufin Enters the Photodynamic Therapy Arena: A Monoamine Oxidase Activatable Photosensitizer for Highly Efficient and Selective Cytotoxicity
Almammadov, T.; Atakan, G.; Leylek, O.; Ozcan, G.; Gunbas, G.; Kolemen, S. Resorufin Enters the Photodynamic Therapy Arena: A Monoamine Oxidase Activatable Photosensitizer for Highly Efficient and Selective Cytotoxicity. ACS Med. Chem. Lett. 2020, 11, 2491-2496.
Mitochondria Targeting Selenophene Modified BODIPY-Based Photosensitizers for Treatment of Hypoxic Tumors
Karaman, O.; Almammadov, T.; Gedik, M. E.; Gunaydin, G.; Kolemen, S.; Gunbas, G. Mitochondria Targeting Selenophene Modified BODIPY-Based Photosensitizers for Treatment of Hypoxic Tumors. ChemMedChem, 2019, 14, 1879-1886.
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Temmuz 19, 2024
Dr. Toghrul Almammadov from Koç University is going to be at SABITALKS on July 24, 2024 at 16:00. The event will take place in person. You […]